2-(Trimethylsilyl)ethoxymethyl chloride Five Chongqing Chemdad Co. ，Ltd

Product

2-(Trimethylsilyl)ethoxymethyl chloride

CAS No.：76513-69-4

Other grades of this product :

2-(Trimethylsilyl)ethoxymethyl chloride Basic information

Product Name:	2-(Trimethylsilyl)ethoxymethyl chloride
Synonyms:	SEM-CHLORIDE;SEM-CI;SEM-CL;2-(TRIMETHYLSILYL)ETHOXYMETHYL CHLORIDE;2-(CHLOROMETHOXY)ETHYLTRIMETHYLSILANE;CHLOROMETHYL 2-TRIMETHYLSILYLETHYL ETHER;2-(Trimethylsilyl)ethoxymethyl chloride ,95% [0.1% diisopropylethylamine as stabilizer];2-(triMethylsilyl)ethoxyMethyl chl
CAS:	76513-69-4
MF:	C6H15ClOSi
MW:	166.72
EINECS:	278-483-4
Product Categories:	Aliphatics;Biochemistry;Protection & Derivatization Reagents (for Synthesis);Reagents for Oligosaccharide Synthesis;Si (Classes of Silicon Compounds);Si-(C)4 Compounds;Silicon Compounds (for Synthesis);Synthetic Organic Chemistry
Mol File:	76513-69-4.mol

2-(Trimethylsilyl)ethoxymethyl chloride Chemical Properties

Boiling point	170-172 °C (lit.) 57-59 °C/8 mmHg (lit.)
density	0.942 g/mL at 25 °C (lit.)
refractive index	n20/D 1.435(lit.)
Fp	116 °F
storage temp.	2-8°C
solubility	Sol most organic solvents (pentane, CH2Cl2, Et2O, THF, DMF, DMPU, HMPA)
form	Liquid
color	Clear colorless
Specific Gravity	0.95
Water Solubility	decomposes
Sensitive	Moisture Sensitive
Hydrolytic Sensitivity	7: reacts slowly with moisture/water
BRN	3587289
InChIKey	BPXKZEMBEZGUAH-UHFFFAOYSA-N
CAS DataBase Reference	76513-69-4(CAS DataBase Reference)

Safety Information

Hazard Codes	C
Risk Statements	10-34
Safety Statements	26-28-36/37/39-45-16
RIDADR	UN 2920 8/PG 2
WGK Germany	3
F	8-10-21
TSCA	No
HazardClass	3.2
PackingGroup	III
HS Code	29319090

MSDS Information

Provider	Language
2-(Trimethylsilyl)ethoxymethyl chloride	English
SigmaAldrich	English
ACROS	English

2-(Trimethylsilyl)ethoxymethyl chloride Usage And Synthesis

Chemical Properties	Colorless to light yellow liqui
Physical properties	bp 57–59 °C/8 mmHg; d 0.942 g cm?3.
Uses	2-(Chloromethoxy)ethyltrimethylsilane is used in the preparation of SEM [2-(trimethylsilyl)ethoxy]methyl]-ethers. It serves as a phenol protecting group in the synthesis of laterifluorones. Further, it reacts with 1H-imidazole to prepare 1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazole.
Uses	2-(Trimethylsilyl)ethoxymethyl Chloride is a reagent used in the protection of alcohols, secondary aryl amines, and imidazole, indole, and pyrrole nitrogens;electrophilic formaldehyde equivalent; acyl anion equivalent,used in One-carbon Homologations, Cyclizations etc.
Uses	Phenol protecting group in the synthesis of laterifluorones.
General Description	2-(Trimethylsilyl)ethoxymethyl chloride (SEM-Cl) is a widely used reagent for the preparation protection groups for amines, alcohols, phenols, and carboxy groups. The nitrogen of amides and sulfonamides groups are also protected by using SEM-Cl reagent.
Purification Methods	Dissolve SEMCl in pentane, dry it (MgSO4), evaporate and distil the residual oil in a vacuum. Stabilise it with 10ppm of diisopropylamine. Store it under N2 in a sealed container in a refrigerator. [Lipshutz & Pegram Tetrahedron Lett 21 3343 1980.]

2-(Trimethylsilyl)ethoxymethyl chloride Preparation Products And Raw materials

Raw materials	2-(Trimethylsilyl)ethanol-->1-BROMO-2-CHLOROMETHOXY-ETHANE
Preparation Products	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-([2-(trimethylsilyl)ethoxy]methyl)-1H-pyrazole

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873