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| 4-Nitrophenylacetic acid Basic information |
| 4-Nitrophenylacetic acid Chemical Properties |
| Melting point | 150-155 °C(lit.) | | Boiling point | 314.24°C (rough estimate) | | density | 1.4283 (rough estimate) | | refractive index | 1.5468 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | pka | 3.85(at 25℃) | | form | Crystalline Powder | | color | Beige to yellow | | PH | 2.98 at 22.8℃ and 10g/L | | Water Solubility | slightly soluble | | Merck | 14,6621 | | BRN | 1911801 | | InChIKey | YBADLXQNJCMBKR-UHFFFAOYSA-N | | LogP | 0.3 at 30℃ and pH7.72 | | CAS DataBase Reference | 104-03-0(CAS DataBase Reference) | | EPA Substance Registry System | 4-Nitrophenylacetic acid (104-03-0) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | RIDADR | UN 3077 9 / PGIII | | WGK Germany | 3 | | RTECS | AJ1130010 | | Hazard Note | Irritant | | TSCA | Yes | | HS Code | 29163900 | | Toxicity | dnr-bcs 500 mg/disc MUREAV170,11,86 |
| 4-Nitrophenylacetic acid Usage And Synthesis |
| Chemical Properties | Beige to yellow crystalline powder | | Uses | Intermediate for dyestuffs, pharmaceuticals,
penicillin precursors, local anesthetics. | | Uses | (4-Nitrophenyl)acetic Acid used in the synthesis of 5,7-dimethyl-2-aryl-3H-pyrrolizin-3-ones which may act as angiogenesis inhibitors. Also used in the one step construction of amino-substituted squaraine dye. | | Definition | ChEBI: A monocarboxylic acid that is phenylacetic acid carrying a nitro substituent at position 4. | | Safety Profile | Moderately toxic intraperitoneal route. Mutation data reported. When heated to decomposition it emits toxic vapors of NOx. | | Purification Methods | Crystallise the acid from EtOH/water (1:1), then from sodium-dried diethyl ether and dry it over P2O5 in vacuo. The styphnate has m 196.5-197o (prisms from EtOH). The amide has m 191o (from EtOH). [Beilstein 9 III 2284, 9 IV 1698.] |
| 4-Nitrophenylacetic acid Preparation Products And Raw materials |
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