1,4-Bis(diphenylphosphino)butane

CAS No.：7688-25-7

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1,4-Bis(diphenylphosphino)butane Basic information

Product Name:	1,4-Bis(diphenylphosphino)butane
Synonyms:	[4-(Diphenylphosphino)butyl](diphenyl)phosphine;TETRAMETHYLENEBIS(DIPHENYLPHOSPHINE);98% DPPB;Tetramethylenebis(diphenylphosphine) DPPB;1,4-Bis(diphenylphosphino)butane, 98% 5GR;1,4-Bis(diphenylphosphiNA)butane;1,4-Bis(diphenylphosphino)buta;1,4-Bis(diphenylphosphino)butane Butane-1,4-diylbis[diphenylphosphine]
CAS:	7688-25-7
MF:	C28H28P2
MW:	426.47
EINECS:	231-698-7
Product Categories:	Phosphines;Phosphine Ligands;Ligand;Synthetic Organic Chemistry;Achiral Phosphine;Aryl Phosphine;organophosphine ligand
Mol File:	7688-25-7.mol

1,4-Bis(diphenylphosphino)butane Chemical Properties

Melting point	132-136 °C (lit.)
Boiling point	542.0±33.0 °C(Predicted)
storage temp.	Inert atmosphere,Room Temperature
form	Crystalline Powder
color	White to almost white
Water Solubility	Soluble in chloroform. Slightly soluble in water
BRN	706446
InChIKey	BCJVBDBJSMFBRW-UHFFFAOYSA-N
CAS DataBase Reference	7688-25-7(CAS DataBase Reference)
NIST Chemistry Reference	1,4-Bis(diphenylphosphino)butane(7688-25-7)
EPA Substance Registry System	Phosphine, 1,4-butanediylbis[diphenyl- (7688-25-7)

Safety Information

Hazard Codes	Xi,F
Risk Statements	36/38-36/37/38-11
Safety Statements	26-36-37/39-33-16-7/9
WGK Germany	3
F	10-23
TSCA	Yes
HS Code	29319090

MSDS Information

Provider	Language
1,4-Bis(diphenylphosphino)butane	English
ACROS	English
SigmaAldrich	English
ALFA	English

1,4-Bis(diphenylphosphino)butane Usage And Synthesis

Chemical Properties	white to light yellow crystal powde
Uses	suzuki reaction
Uses	1,4-Bis(diphenylphosphino)butane is used in Suzuki reaction. It plays an essential role as a ligand in palladium(0)-catalyzed acylcyanation of arylacetylenes and deprotection of allyloxycarbamates. It acts as a ligand for alkylations, isomerization reactions and in organometallic chemistry. Further, it is used in Heck reaction, Negishi coupling and Sonogashira coupling. In addition to this, it is useful in organometallic chemistry.
Purification Methods	Recrystallise it from EtOH [Trippett J Chem Soc 4263 1961]. [King J Coord Chem 1 62 1971, Tolman Chem Rev 77 313 1977.]

1,4-Bis(diphenylphosphino)butane Preparation Products And Raw materials

Raw materials

Ethanol-->Sodium hydroxide-->Hydrochloric acid-->Ethyl acetate-->Tetrahydrofuran-->Dichloromethane-->Sodium-->Magnesium sulfate-->Acetone-->n-Butyllithium-->Triphenylphosphine-->Lithium-->Diphenylphosphine-->1,4-Dibromobutane-->1,4-Dichlorobutane-->Diphenyl[4-(diphenylphosphinyl)butyl]phosphine oxide

Preparation Products

(S)-(-)-7,7'-BIS[DI(3,5-DIMETHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE-->(R)-7,7'-BIS(DIPHENYLPHOSPHINO)-1,1'-SPIROBIINDANE-->(R)-(+)-7,7'-BIS(DIPHENYLPHOSPHINO)-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE-->(S)-7,7'-Bis[di(p-methylphenyl)phosphino]-1,1'-spirobiindane ,97%-->(R)-(+)-7,7'-BIS[DI(4-METHYLPHENYL)PHOSPHINO]-2,2',3,3'-TETRAHYDRO-1,1'-SPIROBIINDANE-->(4-chlorobutyl)diphenylphosphane-->TETRAPHENYLBIPHOSPHINE

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