(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

CAS No.：1062580-52-2

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(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Basic information

Product Name:	(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
Synonyms:	CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE);cis-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride;cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride 95+%;cis-1-Benzyl-N3,4-dimethylpiperidin-3-amine dihydrochloride;(3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE;(3R,4R)-1-benzyl-N,4-diMethylpiperidin-3-aMine BIS-(HYDROCHLORIDE);(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride;3-PiperidinaMine, N,4-diMethyl-1-(phenylMethyl)-, hydrochloride (1:2), (3R,4R)-
CAS:	1062580-52-2
MF:	C14H24Cl2N2
MW:	291.25976
EINECS:
Product Categories:
Mol File:	Mol File

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Chemical Properties

Melting point	249～251℃
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
form	Solid
color	White to Off-White

Safety Information

HazardClass	IRRITANT
HS Code	2933399990

MSDS Information

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Usage And Synthesis

Uses	(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.
Uses	(3R,?4R)?-N,?4-?Dimethyl-?1-?(phenylmethyl)?-3-?piperidinamine Hydrochloride is a related compound of Tofacitinib (T528000). (3R,?4R)?-N,?4-?Dimethyl-?1-?(phenylmethyl)?-3-?piperidinamine Hydrochloride can be used to prepare janus kinase 1 selective inhibitor.
Synthesis	The TiCl4(0.2g, 1mmol), NEt3(0.15g, 1 . 5mmol) suspended 200 ml in toluene, then add 1-benzyl-4-methyl-3-ketone piperidine (20.3g, 100mmol), temperature control 35 °C methylamine solution is added to the reaction solution (9.32g, 120mmol) reaction 4 hours, adding NaBH (OAC) 3 (0.32g, 1 . 5mmol), glacial acetic acid 2 ml, temperature control 35 °C reaction, thin layer monitoring after the reaction is complete. Adding saturated salt water washing, anhydrous sodium sulfate for drying the organic phase, the organic phase concentrated, with residues 35% hydrochloric acid ethanol re-crystallization, to obtain (3R, 4R)-cis-1-benzyl-4-methyl-3-methylamino-piperidine dihydrochloride 17.2g, yield 85.0%, optical purity 99.0% (HPLC method).

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Preparation Products And Raw materials

Raw materials

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine-->1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE-->1-benzyl-4-methylpiperidin-3-one-->(1-Benzyl-4-Methyl-1,2,5,6-tetrahydropyridin-3-yl)carbaMic acid Methyl ester-->Methanamine Acetate-->3-Amino-4-methylpyridine

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