Tropine

Tropine
  • CAS No.:120-29-6
Other grades of this product :
Tropine Basic information
Product Name:Tropine
Synonyms:TIMTEC-BB SBB006506;N-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-OL;TROPINE;TROPAN-3ALPHA-OL;TROPANOL;TRIUNDECENOIN (10C);tropine,tropinol;TROPINE(α TROPINE, TROPINOL)
CAS:120-29-6
MF:C8H15NO
MW:141.21
EINECS:204-384-2
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;TROSPIUM CHLORIDE;Alkaloids;Biochemistry;Tropane Alkaloids
Mol File:120-29-6.mol
Tropine Chemical Properties
Melting point 50-60 °C(lit.)
Boiling point 233 °C(lit.)
density 1.045 g/mL at 25 °C(lit.)
refractive index 1.4811 (estimate)
Fp 232-234°C
storage temp. Inert atmosphere,2-8°C
solubility H2O: 0.1 g/mL, clear
form Crystalline Powder
pka3.80(at 15℃)
color White to slightly yellow
PH12 (100g/l, H2O, 20℃)
Water Solubility 100 g/L (20 ºC)
Sensitive Hygroscopic
Merck 14,9781
BRN 80188
InChIKeyCYHOMWAPJJPNMW-JIGDXULJSA-N
CAS DataBase Reference120-29-6(CAS DataBase Reference)
NIST Chemistry ReferenceTropine(120-29-6)
EPA Substance Registry System8-Azabicyclo[3.2.1]octan-3-ol, 8-methyl-, (3-endo)- (120-29-6)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 26/28-20/22
Safety Statements 22-24/25
RIDADR 1544
WGK Germany 3
RTECS YM3875000
3
Hazard Note Irritant
TSCA Yes
HazardClass 6.1(b)
PackingGroup III
HS Code 29399990
MSDS Information
ProviderLanguage
Tropine English
SigmaAldrich English
ALFA English
Tropine Usage And Synthesis
Chemical Propertieswhite to slightly yellow crystalline powder
UsesTropine is an oxidative product of Tropane, used to synthesize alkaloid derivatives.
UsesTropine as an oxidative product of Tropane, used to synthesize alkaloid derivatives. Benzatropine and etybenzatropine are derivatives of tropine. It is also a building block of atropine, an anticholinergic drug prototypical of the muscarinic antagonist class.
DefinitionChEBI: A derivative of tropane having a hydroxy group at the 3-position.
Purification MethodsDistil 3-tropanol in steam and crystallise it from Et2O or toluene/pet ether. It sublimes at 60o/0.1mm. Hygroscopic. The hydrochloride has m 280o (from EtOH/Et2O). [Beilstein 21 H 16, 21 I 197, 21 II 17, 21 III/IV 168, 21/1 V 219.]
Tropine Preparation Products And Raw materials
Preparation Productscyclamen aldehyde-->TROPYL A ORMULPHENYLACETATE-->Flutropium bromide-->Lily aldehyde-->RETAPAMULIN-->ACETYLHOMATROPINE-->Tropisetron

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