5-Amino-4-imidazolecarboxamide

CAS No.：360-97-4

Other grades of this product :

5-Amino-4-imidazolecarboxamide Basic information

Description Reference

Product Name:	5-Amino-4-imidazolecarboxamide
Synonyms:	4-AMINOIMIDAZOLE-5-CARBOXAMIDE;4-amino-5-imidazolecarboxamid;5-amino-1h-imidazole-4-carboxamid;5-Amino-4-glyoxalinecarboxamide;5-amino-imidazole-4-carboxamid;5-amino-4-imidazolecarboxamide;5-AMINOIMIDAZOLE-4-CARBOXAMIDE;5-AMINO-1H-IMIDAZOLE-4-CARBOXAMIDE
CAS:	360-97-4
MF:	C4H6N4O
MW:	126.12
EINECS:	206-641-4
Product Categories:	Amines;Amines, Metabolites & Impurities, Nucleotides, Bases & Related Reagents;pharmacetical;Building Blocks;Heterocyclic Building Blocks;Imidazoles;Imidazol&Benzimidazole;Various Metabolites and Impurities;Bases & Related Reagents;Metabolites & Impurities;Nucleotides;bc0001
Mol File:	360-97-4.mol

5-Amino-4-imidazolecarboxamide Chemical Properties

Melting point	164-170 °C(lit.)
Boiling point	234.22°C (rough estimate)
density	1.3659 (rough estimate)
refractive index	1.8500 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
pka	11.97±0.10(Predicted)
form	Powder
color	White
Water Solubility	Soluble in DMSO, Methanol, Water.
InChIKey	DVNYTAVYBRSTGK-UHFFFAOYSA-N
CAS DataBase Reference	360-97-4(CAS DataBase Reference)
EPA Substance Registry System	1H-Imidazole-4-carboxamide, 5-amino- (360-97-4)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	NI3910000
TSCA	Yes
HS Code	29332900

MSDS Information

Provider	Language
SigmaAldrich	English

5-Amino-4-imidazolecarboxamide Usage And Synthesis

Description	5-Amino-4-imidazolecarboxamide may be used in the synthesis of 4-(N′-benzoylcarbamoyl)amino-5-imidazolecarboxamide and 5-amino-1-β-D-ribosyl-4-imidazolecarboxamide-5′-phosphate (AICAR).It is an imidazole derivative which is a metabolite of the antineoplastic agents BIC and DIC. By itself, or as the ribonucleotide, it is used as a condensation agent in the preparation of nucleosides and nucleotides. When compounded with orotic acid, it is used to treat liver diseases.
Reference	3. Black, S. L., M. J. Black, and J. H. Mangum. "A rapid assay for 5-amino-4-imidazolecarboxamide ribotide transformylase." Analytical Biochemistry90.1(1978):397-401.
Chemical Properties	White to Off-White Solid
Uses	A metabolite of Temozolomide
Uses	4-Aminoimidazole-5-carboxamide is used as Catalytic agent, Petrochemical additive. It is metabolite of temozolomide.
Uses	5-Amino-4-imidazolecarboxamide may be used in the synthesis of 4-(N′-benzoylcarbamoyl)amino-5-imidazolecarboxamide and 5-amino-1-β-D-ribosyl-4-imidazolecarboxamide-5′-phosphate (AICAR).
Definition	ChEBI: An aminoimidazole in which the amino group is at C-5 with a carboxamido group at C-4.

5-Amino-4-imidazolecarboxamide Preparation Products And Raw materials

Raw materials	Glycinamide
Preparation Products	Temozolomide-->Dacarbazine-->5-(Amino-1-(N-methyl Carbamoyl)-->ETHYL 4-AMINO-5-IMIDAZOLECARBOXYLATE

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