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| O-PHOSPHORYLETHANOLAMINE Basic information |
| Product Name: | O-PHOSPHORYLETHANOLAMINE | | Synonyms: | ETHANOLAMINE PHOSPHATE;2-HYDROXYETHYLAMMONIUM DIHYDROGEN PHOSPHATE;2-HYDROXYETHYLAMINE ACID PHOSPHATE;2-AMINOETHANOL DIHYDROGEN PHOSPHATE;2-AMINOETHYL DIHYDROGEN PHOSPHATE;O-PHOSPHOETHANOLAMINE;O-PHOSPHORYLETHANOLAMINE;O-PHOSPHOCOLAMINE | | CAS: | 1071-23-4 | | MF: | C2H8NO4P | | MW: | 141.06 | | EINECS: | 213-988-5 | | Product Categories: | Pharmaceutical Intermediates | | Mol File: | 1071-23-4.mol |
| O-PHOSPHORYLETHANOLAMINE Chemical Properties |
| Hazard Codes | T,C | | Risk Statements | 25-34 | | Safety Statements | 26-36/37/39-45-27 | | RIDADR | UN 3261 8/PG 2 | | WGK Germany | 3 | | RTECS | KJ5830000 | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29221990 | | Toxicity | LD50 orally in Rabbit: 5820 mg/kg |
| O-PHOSPHORYLETHANOLAMINE Usage And Synthesis |
| Chemical Properties | O-PHOSPHORYLETHANOLAMINE is white powder
| | Uses | O-PHOSPHORYLETHANOLAMINEe is used in the synthesis of Sphingomyelin, a type of sphingolipid found in animal cell membrane.
| | Uses | O-Phosphorylethanolamine has been used:- in LHC-8 medium as a supplement in culturing the transformed human liver epithelial (THLE)-2 and THLE-3 cells
- in C-reactive protein (CRP) binding sucrose flotation experiment
- to incubate phosphomonoesters with anion-exchange chromatography (AEC) fractions for the detection of phosphatase activity
- to add in the washed beads for the preparation of phosphorylethanolamine (Pet) -conjugated sepharose column for chromatographic purification of mutant CRP
| | Definition | ChEBI: The ethanolamine mono-ester of phosphoric acid, and a metabolite of phospholipid metabolism. This phosphomonoester shows strong structural similarity to the inhibitory neurotransmitter GABA, and is decreased in post-mortem Alzheimer's disease brain. | | Biochem/physiol Actions | Phosphorylethanolamine participates in phospholipid metabolism. Its release can be stimulated occasionally by depolarizing stimuli. Reduction of phosphorylethanolamine levels has been observed in Alzheimer′s and Huntington′s disease. | | Purification Methods | Purification by recrystallisation from aqueous EtOH gives a hydrate (m 140-141o). Its solubility in H2O is 17% and 0.003% in MeOH or EtOH at 22o. [F.lisch & .sterberg J Biol Chem 234 2298 1959, Baer & Staucer Can J Chem 34 434 1956, Christensen J Biol Chem 135 399 1940.] It is a potent inhibitor of ornithine decarboxylase [Gilad & Gilad Biochem Biophys Res Commun 122 277 1984]. [Beilstein 4 IV 1415.] |
| O-PHOSPHORYLETHANOLAMINE Preparation Products And Raw materials |
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