Product

3,5-Dimethylpyrazole

CAS No.：67-51-6

Other grades of this product :

3,5-Dimethylpyrazole Basic information

Product Name:	3,5-Dimethylpyrazole
Synonyms:	TIMTEC-BB SBB004377;LABOTEST-BB LT00107055;1(H)-3,5-Dimethylpyrazole;1H-Pyrazole,3,5-dimethyl-;3,5-dimethyl-1h-pyrazol;3,5-Dwumetylopirazolu;Pyrazole, 3,5-dimethyl-;TH 564
CAS:	67-51-6
MF:	C5H8N2
MW:	96.13
EINECS:	200-657-5
Product Categories:	Pharmaceutical intermediates;Building Blocks;Building Blocks;C3 to C5;Chemical Synthesis;Heterocyclic Building Blocks;Heterocyclic Building Blocks;Pyrazoles;Gravimetric ReagentsBuilding Blocks;Analytical Reagents;Analytical/Chromatography;Diketene Derivatives;Pyrazolones;bc0001
Mol File:	67-51-6.mol

3,5-Dimethylpyrazole Chemical Properties

Melting point	105-108 °C (lit.)
Boiling point	218 °C (lit.)
density	0,884 g/cm³
refractive index	1.4739 (estimate)
Fp	210°C
storage temp.	Sealed in dry,Room Temperature
solubility	methanol: 0.1 g/mL, clear
pka	15.12±0.10(Predicted)
form	Crystalline Powder or Crystals
color	White to almost white
PH	6.7 (14g/l, H2O, 20℃)
Water Solubility	Soluble in water, methanol 0.1 g/mL.
BRN	106325
InChIKey	SDXAWLJRERMRKF-UHFFFAOYSA-N
CAS DataBase Reference	67-51-6(CAS DataBase Reference)
NIST Chemistry Reference	1H-Pyrazole, 3,5-dimethyl-(67-51-6)
EPA Substance Registry System	3,5-Dimethylpyrazole (67-51-6)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38
Safety Statements	26-36
WGK Germany	3
RTECS	UQ6477600
TSCA	Yes
HazardClass	IRRITANT
HS Code	29331990

MSDS Information

Provider	Language
3,5-Dimethylpyrazole	English
ACROS	English
SigmaAldrich	English
ALFA	English

3,5-Dimethylpyrazole Usage And Synthesis

Chemical Properties	White crystal powder
Uses	Common reagent for the preparation of pyrazolato ligated complexes.1,2 Also used to prepare N-1-substituted derivatives having antibacterial activity.3
Uses	3,5-Dimethylpyrazole is used as intermediate for the manufacture of organic dyestuffs and photochemicals. Product Data Sheet
Uses	3,5-Dimethylpyrazole his a catalyst in the sulfonation of acetic anhydride to sulfoacetic acid and methanedisulfonic acid. 3,5-Dimethylpyrazole has been used in the synthesis of bipyrazolic tripodal derivatives with in vitro antitumor, antifungal and antibacterial activities.
Synthesis Reference(s)	Journal of Heterocyclic Chemistry, 19, p. 373, 1982 DOI: 10.1002/jhet.5570190231Organic Syntheses, Coll. Vol. 4, p. 351, 1963
Purification Methods	Crystallise it from cyclohexane or water. [Barszez et al. J Chem Soc, Dalton Trans 2025 1986, Beilstein 23/5 V 110.]

3,5-Dimethylpyrazole Preparation Products And Raw materials

Raw materials

1H-Pyrazole, 3,5-dimethyl-1-[2-[(4-methylphenyl)sulfonyl]ethyl]--->1-(4-methoxyphenyl)-3,5-dimethyl-1H-Pyrazole-->ETHYL 3-AMINO-4,6-DIMETHYLTHIENO[2,3-B]PYRIDINE-2-CARBOXYLATE-->1-ALLYL-3 5-DIMETHYLPYRAZOLE 96-->1-CYANOACETYL-3,5-DIMETHYLPYRAZOLE-->4-Bromo-3,5-dimethylpyrazole-->Semicarbazide hydrochloride-->Hydrazine hydrate-->2,3-Pentanedione

Preparation Products

4-Bromo-1,3,5-trimethyl-1H-pyrazole-->(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)METHYLAMINE-->1,3,5-Trimethylpyrazole-->1,3,5-Trimethyl-1H-pyrazole-4-carboxaldehyde-->3,5-PYRAZOLEDICARBOXYLIC ACID-->1,3,5-TRIMETHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID-->1H-Pyrazole-4-carbonyl chloride, 1,3,5-trimethyl- (9CI)-->1,4-Dioxaspiro[4.5]decan-8-one-->DIETHYL 3,5-PYRAZOLEDICARBOXYLATE-->3,5-DIMETHYLPYRAZOLE-1-METHANOL-->4-amino-3,5-dimethyl-pyrazol-->Benzenesulfonic acid, 3-[2-[4-[2-(3,5-dimethyl-1H-pyrazol-4-yl)diazenyl]-2,5-dimethoxyphenyl]diazenyl]-, sodium salt (1:1)

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