(R)-(-)-3-Quinuclidinol

CAS No.：25333-42-0

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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(R)-(-)-3-Quinuclidinol Basic information

Product Name:	(R)-(-)-3-Quinuclidinol
Synonyms:	Solifenacin Succinate interMediate C;(R)-(-)-3-Quinuclidinol-4;(R)-Quinuclidinol;(R)-3-Quinuclinol;(R)-1-Azabicyclo[2.2.2]octan-3-ol,99%e.e.;Solifenacin EP Impurity E;Solifenacin Related Compound 10;Solifenacin Impurity 4
CAS:	25333-42-0
MF:	C7H13NO
MW:	127.18
EINECS:	246-857-6
Product Categories:	Heterocycles;Intermediates & Fine Chemicals;Chiral Reagents;Pharmaceuticals
Mol File:	25333-42-0.mol

(R)-(-)-3-Quinuclidinol Chemical Properties

Melting point	217-224 °C
alpha	-44.5 º (c=3, 1N HCl)
Boiling point	120 °C (20.2527 mmHg)
density	1.0083 (rough estimate)
vapor pressure	0.006-0.016Pa at 20-25℃
refractive index	1.4830 (estimate)
storage temp.	Flammables area
pka	14.75±0.20(Predicted)
form	Crystalline Powder
color	White to faintly beige
Water Solubility	100 g/100 mL
LogP	-2.8 at 20℃ and pH7
CAS DataBase Reference	25333-42-0(CAS DataBase Reference)

Safety Information

Hazard Codes	C-F,C,F
Risk Statements	34-11
Safety Statements	45-36/37/39-26-16
RIDADR	3263
HS Code	29339980

MSDS Information

Provider	Language
(R)-(-)-1-Azabicyclo[2.2.2]octan-3-ol	English
ACROS	English

(R)-(-)-3-Quinuclidinol Usage And Synthesis

Chemical Properties	White Solid
Uses	Hypotensive. Synthon for preparation of cholinergic receptor ligands and anesthetics
Uses	Sitagliptin phosphate?intermediate

(R)-(-)-3-Quinuclidinol Preparation Products And Raw materials

Raw materials

Ethanol-->Sodium hydroxide-->Hydrochloric acid-->Tetrahydrofuran-->Potassium carbonate-->Acetic anhydride-->Acetonitrile-->Sodium borohydride-->Isopropyl alcohol-->Ethyl chloroacetate-->Potassium tert-butoxide-->Ethyl bromoacetate-->L(+)-Tartaric acid-->D-Tartaric acid-->Ethyl 4-piperidinecarboxylate-->L-Malic acid-->(1R)-(-)-10-Camphorsulfonic acid

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