N-Boc-3-pyrrolidinone

CAS No.：101385-93-7

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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N-Boc-3-pyrrolidinone Basic information

Product Name:	N-Boc-3-pyrrolidinone
Synonyms:	N-Boc-3-pyrolidinone;3,5-Dichloro-4-Formyl Pydidine;1-tert-Butoxycarbonyl-3-pyrrolidone;1-N-Boc-3-pyrrolidinone ,98%;1,1-DiMethylethyl 3-Oxopyrrolidine-1-carboxylate;N-BOC-3-Pyrrolodinone;1-Boc-3-pyrrolidone 1-tert-Butoxycarbonyl-3-pyrrolidinone 1-Boc-3-pyrrolidinone tert-Butyl 3-Oxopyrrolidine-1-carboxylate 3-Oxopyrrolidine-1-carboxylic Acid tert-Butyl Ester;Pyrrolidin-3-one, N-BOC protected 97%
CAS:	101385-93-7
MF:	C9H15NO3
MW:	185.22
EINECS:	600-204-5
Product Categories:	Omarigliptin intermediates;CHIRAL CHEMICALS;pharmacetical;Benzenes;Aliphatics;Heterocycles;Amines and Anilines;Carbonyl Compounds;Pyrrolidines;Pyrrole&Pyrrolidine&Pyrroline
Mol File:	101385-93-7.mol

N-Boc-3-pyrrolidinone Chemical Properties

Melting point	34-38 °C (lit.)
Boiling point	270.9±33.0 °C(Predicted)
density	1.133±0.06 g/cm3(Predicted)
Fp	>230 °F
storage temp.	2-8°C
solubility	Dichloromethane, Ethyl Acetate, Methanol
pka	-1.79±0.20(Predicted)
form	Low Melting Solid
color	White to yellow to orange
Water Solubility	Insoluble in water.
InChIKey	JSOMVCDXPUXKIC-UHFFFAOYSA-N
CAS DataBase Reference	101385-93-7(CAS DataBase Reference)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-37/38-41-36/37/38-20/21/22
Safety Statements	26-36/37/39-36
WGK Germany	3
Hazard Note	Irritant
HS Code	29339900

MSDS Information

Provider	Language
SigmaAldrich	English

N-Boc-3-pyrrolidinone Usage And Synthesis

Chemical Properties	Brown Oil
Uses	In the Synthesis and antibacterial evaluation of a novel series of rifabutin-like spirorifamycins 1-Boc-3-pyrrolidinone is used.
Uses	Used in a study of asymmetric hydrogen-transfer bioreduction of ketones with Leifsonia alcohol dehydrogenase.

N-Boc-3-pyrrolidinone Preparation Products And Raw materials

Raw materials

tert-Butyl 3-aminopyrrolidine-1-carboxylate-->1-Benzyl-3-pyrrolidinone-->(R)-(+)-1-Boc-3-aminopyrrolidine-->(R)-1-Boc-3-hydroxypyrrolidine-->3-(tert-Butoxycarbonyl-ethoxycarbonylmethyl-amino) -propionic acid ethyl ester-->Ethyl N-Boc-4-Oxopyrrolidine-3-carboxylate-->N-(tert-Butoxycarbonyl)-(S)-(+)-3-pyrrolidinol-->3-Pyrrolidinol-->1-(tert-Butoxycarbonyl)-3-pyrrolidinol-->2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile

Preparation Products

1-BOC-3-CYANO-3-FLUOROPYRROLIDINE-->3-Methyl-3-Pyrrolidinol hydrochloride-->tert-butyl 2-(Methylsulfonyl)-4,6-dihydropyrrolo[3,4-c]pyrazole-5(2H)-carboxylate-->1-BOC-2,3-Dihydropyrrole-4-boronic acid, pinacol ester-->1-N-Boc-3-Cyanopyrrolidine--> 1-Boc-2,5-Dihydro-1H-pyrrole-3-boronic acid, pinacol ester

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