1,4-BIS(2-HYDROXYETHYL)PIPERAZINE

CAS No.：122-96-3

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Basic information

Product Name:	1,4-BIS(2-HYDROXYETHYL)PIPERAZINE
Synonyms:	DI(HYDROXYETHYL)PIPERAZINE;AKOS BB-4936;2-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]ETHANOL;1,4'-BIS(2-HYDROXYETHYL)PIPERAZINE;1,4-BIS(2-HYDROXYETHYL)PIPERAZINE;1,4-PIPERAZINEDIETHANOL;1,4-Bis(beta-hydroxyethyl)piperazine;1,4-Di(2-hydroxyethyl)piperazine
CAS:	122-96-3
MF:	C8H18N2O2
MW:	174.24
EINECS:	204-586-0
Product Categories:	PIPERIDINE
Mol File:	122-96-3.mol

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Chemical Properties

Melting point	133.5-136 °C(lit.)
Boiling point	215-220 °C50 mm Hg(lit.)
density	1.097
vapor pressure	0.004Pa at 20℃
refractive index	1.4540 (estimate)
Fp	166℃
storage temp.	Sealed in dry,Room Temperature
form	powder to crystal
pka	14.66±0.10(Predicted)
color	White to Almost white
Water Solubility	Soluble in water.
InChIKey	VARKIGWTYBUWNT-UHFFFAOYSA-N
LogP	-1.92 at 20℃
CAS DataBase Reference	122-96-3(CAS DataBase Reference)
EPA Substance Registry System	1,4-Piperazinediethanol (122-96-3)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	37/39-26
WGK Germany	3
RTECS	TL3675000
TSCA	Yes

MSDS Information

Provider	Language
SigmaAldrich	English
ACROS	English

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Usage And Synthesis

Chemical Properties	white crystalline powder
Uses	1,4-Piperazinediethanol is useful in the synthesis of salt-inducible kinase inhibitors for the treatment of diseases.
Flammability and Explosibility	Notclassified

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Preparation Products And Raw materials

Raw materials	Ethanol-->Sodium hydroxide-->Hydrochloric acid-->Ethyl acetate-->Dichloromethane-->Potassium carbonate-->Sodium sulfate-->Piperazine-->2-Chloroethanol-->3-(2-HYDROXYETHYL)-2-OXAZOLIDINONE-->ETHYLENE OXIDE-->2-Bromoethanol-->CARBON DIOXIDE
Preparation Products	1-(2-Hydroxyethyl)piperazine

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