(R)-(+)-1-(1-Naphthyl)ethylamine

CAS No.：3886-70-2

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(R)-(+)-1-(1-Naphthyl)ethylamine Basic information

Product Name:	(R)-(+)-1-(1-Naphthyl)ethylamine
Synonyms:	(R) 1-(1-NAPTHYL)ETHYLAMINE;(R)-(+)-1-(1-NAPHTHYL)ETHYLAMINE;(R)-1-(1-NAPHTHYL)ETHYLAMINE;(R)-1-(NAPHTHALEN-1-YL)ETHANAMINE;(R)-(+)-1-(NAPHTHYL)ETHYLAMINE;(R)-(+)-A-(1-NAPHTHYL)ETHYLAMINE;(R)-(+)-ALPHA-(1-AMINOETHYL)NAPHTHALENE;(R)-(+)-ALPHA-(1-NAPHTHYL)ETHYLAMINE
CAS:	3886-70-2
MF:	C12H13N
MW:	171.24
EINECS:	223-425-5
Product Categories:	Cinacalcet Intermediate;Miscellaneous;Amines (Chiral);Analytical Chemistry;Chiral Building Blocks;e.e. / Absolute Configuration Determination (NMR);chiral;Enantiomer Excess & Absolute Configuration Determination;for Resolution of Acids;Optical Resolution;Synthetic Organic Chemistry
Mol File:	3886-70-2.mol

(R)-(+)-1-(1-Naphthyl)ethylamine Chemical Properties

Melting point	135-136 °C
alpha	60 º (c=2, CH3OH)
Boiling point	153 °C11 mm Hg(lit.)
density	1.067 g/mL at 20 °C(lit.)
refractive index	n20/D 1.623(lit.)
Fp	>230 °F
storage temp.	2-8°C
solubility	Chloroform (Slightly), Ethanol (Slightly), Methanol (Slightly)
pka	9.26±0.40(Predicted)
form	Liquid
color	brown
optical activity	[α]20/D +55°, c = 2 in ethanol
Water Solubility	Soluble in water (<10/l).
Sensitive	Air Sensitive
BRN	2208025
Stability:	Stable. Air-sensitive. Incompatible with acids, oxidizing agents, acid anhydrides, chloroformates, acid chlorides.
InChIKey	RTCUCQWIICFPOD-SECBINFHSA-N
CAS DataBase Reference	3886-70-2(CAS DataBase Reference)
EPA Substance Registry System	1-Naphthalenemethanamine, .alpha.-methyl-, (.alpha.R)- (3886-70-2)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	2735
WGK Germany	3
RTECS	QJ6963000
F	10-34
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29211990

MSDS Information

Provider	Language
R-(+)-alpha-(1-Naphthyl)ethylamine	English
ACROS	English
SigmaAldrich	English
ALFA	English

(R)-(+)-1-(1-Naphthyl)ethylamine Usage And Synthesis

Chemical Properties	Colorless to light yellow liqui
Uses	(R)-(+)-1-(1-Naphthyl)ethylamine is used in chiral synthesis in organic reactions including the synthesis of β-amino acids and the enantioselective of ketones to nitroolefins.
Uses	It is used in chiral synthesis in organic reactions including the synthesis of β-amino acids and the enantioselective of ketones to nitroolefins. Also used as absolute configuration of primary amines determined using chiral (2-nitrophenyl)proline amides and H NMR.
General Description	(R)-(+)-1-(1-Naphthyl)ethylamine is a chiral derivatization reagent useful for all gas chromatography (GC) applications in the chiral field. It is specially selected to meet the requirements for derivatization reagents for enantiomeric excess determinations.
Purification Methods	Purify the amine by distillation in a good vacuum. [Mori et al. Tetrahedron 37 1343 1981, cf Wilson in Topics Stereochem (Allinger and Eliel eds) v o l 6 135 1971, Fredga et al. Acta Chem Scand 11 1609 1957.] The hydrochlorides crystallise from H2O [] D 18 ±3.9o (c 3, H2O), and the sulfates recrystallise from H2O as tetrahydrates m 230-232o. The RS-amine has b 153o/11mm, 156o/15mm, 183.5o/41mm [Blicke & Maxwell J Am Chem Soc 6 1 1780 1939]. [Beilstein 12 III 3111.]

(R)-(+)-1-(1-Naphthyl)ethylamine Preparation Products And Raw materials

Raw materials	1-Naphthaldehyde-->D-Plenylglycinol
Preparation Products	1R，3R-chrysanthemic acid-->Cinacalcet hydrochloride-->N-((R)-1-(naphthalen-1-yl)ethyl)-3-(3-(trifluoroMethyl)phenyl)propanaMide-->1-ETHYLNAPHTHALENE-->(+/-)1-(1-Naphthyl)ethylamine

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