4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid

CAS No.：104239-97-6

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid Basic information

Product Name:	4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid
Synonyms:	4-AZA-5ALPHA-ANDROSTA-1-EN-3-ONE-17BETA-CARBOXYLIC ACID;(5APHA,17BETA)-3-OXO-4-AZAANDROST-1-ENE-17-CARBOXYLIC ACID;3-Oxo-4-aza-5a-androst-1-ene-17b-carboxylicAcid;(5alpha,17beta)-3-Oxo-4-azaandrost-1-ene-17-carboxylic acid;4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid;4-AZA-5A-ANDROSTAN-1-ENE-3-ONE-17β-CARBOXYLIC ACID;3-Oxo-4-aza-5a-androst-1-ene-17-carboxylic Acid;3-Oxo-4-aza-5α-αndrost-1-ene-17β-carboxylic Acid
CAS:	104239-97-6
MF:	C19H27NO3
MW:	317.42
EINECS:	1592732-453-0
Product Categories:	Intermediates;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids
Mol File:	104239-97-6.mol

4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid Chemical Properties

Melting point	295-297 °C
Boiling point	527.3±50.0 °C(Predicted)
density	1.166
storage temp.	2-8°C
solubility	Acetonitrile (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated)
pka	4.80±0.60(Predicted)
form	Solid
color	Off-White to Pale Brown

Safety Information

MSDS Information

4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid Usage And Synthesis

Chemical Properties	4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid is Off-White Powder
Uses	4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid is an intermediate in the synthesis of Finasteride, am onhibitor of 5a-reductase, the enzyme which converts testosterone to the more potent androgen, 5a-dihydrotestosterone
Uses	A novel intermediate in the synthesis of Finasteride, a 5α-reductase inhibitor used for treatment of benign prostatic hyperplasia acne, seborrhea, female hirsutism, prostatitis, and prostatic carcinoma and other hyperandrogenetic related disorders.
Uses	A novel intermediate in the synthesis of Finasteride and Dutasteride, a 5α-reductase inhibitors used for treatment of benign prostatic hyperplasia acne, seborrhea, female hirsutism, prostatitis, and p rostatic carcinoma and other hyperandrogenetic related disorders.

4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid Preparation Products And Raw materials

Raw materials

1H-Benz[e]indene-6-propanoic acid, 3-acetyldodecahydro-3a,6-dimethyl-7-oxo-, (3S,3aS,5aS,6R,9aS,9bS)--->1416955-18-4-->2H-Indeno[5,4-f]quinolin-2-one, 7-acetyl-1,3,4,4a,4b,5,6,6a,7,8,9,9a,9b,10-tetradecahydro-4a,6a-dimethyl-, (4aR,4bS,6aS,7S,9aS,9bS)--->NA-->2H-Indeno[5,4-f]quinolin-2-one, 7-acetylhexadecahydro-4a,6a-dimethyl-, (4aR,4bS,6aS,7S,9aS,9bS,11aR)--->BIS(TRIMETHYLSILYL) SULFATE-->METHYL 4-AZA-5ALPHA-ANDROSTA-3-ONE-17BETA-CARBOXYLATE-->METHYL 4-AZA-5ALPHA-ANDROSTA-1-EN-3-ONE-17BETA-CARBOXYLATE-->3-Oxo-4-aza-5-alpha-androstane-17-beta-carboxylic acid-->Dichloromethane-->Methanol-->1,3-Cyclohexanedione

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