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| Deoxyarbutin Basic information |
| Product Name: | Deoxyarbutin | | Synonyms: | Deoxyarbutin;Tetrahydropyranyloxyphenol;4-(TETRAHYDRO-2H-2-PYRANYLOXY)PHENOL;4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenol;Phenol,4-[(tetrahydro-2H-pyran-2-yl)oxy]-;Deoxyarbutin
4-[(Tetrahydro-2H-pyran-2-yl)oxy]phenol;4-[(2-Tetrahydropyranyl)oxy]phenol;LGB-D ARBUTIN | | CAS: | 53936-56-4 | | MF: | C11H14O3 | | MW: | 194.23 | | EINECS: | 1308068-626-2 | | Product Categories: | Inhibitors;Cosmetics;53936-56-4 | | Mol File: | 53936-56-4.mol |
| Deoxyarbutin Chemical Properties |
| Melting point | 88-89 °C(Solv: ligroine (8032-32-4)) | | Boiling point | 349.8±32.0 °C(Predicted) | | density | 1.174 | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Sonicated) | | pka | 10.10±0.15(Predicted) | | form | Solid | | color | White to Off-White | | Stability: | Hygroscopic |
| Deoxyarbutin Usage And Synthesis |
| Description | Deoxyarbutin is a tyrosinase inhibitor (IC50 = 17.5 μM for mushroom tyrosinase). It reduces melanin content in isolated dark human melanocytes when used at a concentration of 1.56 μM. Topical administration of deoxyarbutin (5%) induces skin lightening in human skin mouse xenograft models. Deoxyarbutin also inhibits proliferation of B16/F10 murine melanoma cells (EC50 = 39.56 μM). It induces apoptosis and halts the cell cycle at the S phase in B16/F10 cells when used at a concentration of 50 μM. Deoxyarbutin (50 mg/kg) reduces tumor growth in a B16/F10 murine melanoma model. | | Uses | Deoxyarbutin acts as a skin whitening agent through the inhibition of tyrosinase. A safer alternative to the use of hydroquinone and arbutin. | | Preparation |
Deoxyarbutin is a derivative of ?-arbutin, obtained by removal of hydroxyl groups from the glucose side-chain of ?-arbutin.
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| Deoxyarbutin Preparation Products And Raw materials |
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