Tetrachlorophthalic anhydride

Tetrachlorophthalic anhydride
  • CAS No.:117-08-8

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  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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Tetrachlorophthalic anhydride Basic information
Product Name:Tetrachlorophthalic anhydride
Synonyms:4,5,6,7-TETRACHLORO-1,3-ISOBENZOFURANDIONE;NIATHAL;TETRACHLOROPHTHARIC ANHYDRIDE;TETRACHLOROPHTHALIC ANHYDRIDE;Tetrachloro-1,2-benzenedicarboxylic acid anhydride;TETRACHLORO-1,2-BENZENEDICARBOXYLIC ANHYDRIDE;TETRATHAL;TETRATHAL(R)
CAS:117-08-8
MF:C8Cl4O3
MW:285.9
EINECS:204-171-4
Product Categories:Intermediates of Dyes and Pigments;Anhydride Monomers;Phthalic Acids, Esters and Derivatives;Organics;Monomers;Polymer Science
Mol File:117-08-8.mol
Tetrachlorophthalic anhydride Chemical Properties
Melting point 253-257 °C(lit.)
Boiling point 371 °C(lit.)
density 1.49
vapor pressure 0.16 mm Hg ( 145 °C)
Fp 362°C
storage temp. Store below +30°C.
solubility Chloroform (Slightly, Heated), DMSO (Heated), Methanol (Slightly, Heated)
form Flakes
pka3.01[at 20 ℃]
color White to off-white
Water Solubility 0.8 mg/L (21 ºC)
Sensitive Moisture Sensitive
BRN 211560
Exposure limitsACGIH: TWA 0.002 mg/m3 (Skin)
Stability:Stable. Reacts with water. Combustible. Incompatible with strong oxidizing agents. Air and moisture sensitive.
InChIKeyAUHHYELHRWCWEZ-UHFFFAOYSA-N
LogP3.2 at 25℃
CAS DataBase Reference117-08-8(CAS DataBase Reference)
NIST Chemistry Reference1,3-Isobenzofurandione, 4,5,6,7-tetrachloro-(117-08-8)
EPA Substance Registry SystemTetrachlorophthalic anhydride (117-08-8)
Safety Information
Hazard Codes T,N,Xn
Risk Statements 45-41-42/43-50/53-48/22
Safety Statements 53-22-24-26-37/39-45-60-61-36/37/39
RIDADR UN 3077 9/PG 3
WGK Germany 2
RTECS TI3450000
F 10-21
TSCA Yes
HazardClass 9
PackingGroup III
HS Code 29173990
Hazardous Substances Data117-08-8(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: > 15800 mg/kg LD50 dermal Rabbit > 5000 mg/kg
MSDS Information
ProviderLanguage
4,5,6,7-Tetrachloro-1,3-isobenzofurandione English
ACROS English
SigmaAldrich English
ALFA English
Tetrachlorophthalic anhydride Usage And Synthesis
Chemical Propertieswhite needle-like crystals or powder
UsesIntermediate in dyes, pharmaceuticals, plasticizers, and other organic materials; flame-retardant in epoxy resins.
UsesTetrachlorophthalic Anhydride is used in the synthesis of nucleoside analogues with a specific structure as apoptosis inducing active compounds. Also used in the synthesis of carbonic anhydrase inhbitors. Chlorinated Reactive Flame Retardant Intermediate
DefinitionChEBI: A cyclic dicarboxylic anhydride that is phthalic anhydride chlorinated at the 4-, 5-, 6- and 7-positions.
General DescriptionOdorless needle-like crystals or white powder.
Air & Water ReactionsSensitive to air and moisture.
Reactivity Profile4,5,6,7-Tetrachloro-1,3-isobenzofurandione reacts exothermically with water. This reaction is expected to be slow, but can become vigorous if local heating accelerates it. Reaction with water is accelerated by acids. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.
Fire HazardFlash point data for 4,5,6,7-Tetrachloro-1,3-isobenzofurandione are not available. 4,5,6,7-Tetrachloro-1,3-isobenzofurandione is probably combustible.
Flammability and ExplosibilityNotclassified
Purification MethodsCrystallise the anhydride from chloroform or *benzene, then sublime it in a vacuum. [Beilstein 17/11 V 260.]

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