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| N,N'-Disuccinimidyl carbonate Basic information |
| Product Name: | N,N'-Disuccinimidyl carbonate | | Synonyms: | 2,5-PYRROLIDINEDIONE, 1,1'-[CARBONYLBIS(OXY)]BIS-;di-N,N'-succnimidly carbonat;Carbonic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester;N,Nzzhlxy-Disuccinimidyl carbonate (DSC);Carbonic acid, bis(2,5-dioxo-1-pyrrolidinyl) ester;N-Succinimidyl Carbonate
N,N'-Disuccinimidyl Carbonate
DSC;DI-(N,N'-SUCCINIMIDYL) CARBONATE FOR SYN;N,N-DisucciniMdyl carbonate | | CAS: | 74124-79-1 | | MF: | C9H8N2O7 | | MW: | 256.17 | | EINECS: | 277-730-3 | | Product Categories: | N-Protecting Reagents;Medical Intermediates;Biochemistry;Condensation & Active Esterification;Coupling Reactions (Peptide Synthesis);N-Substituted Maleimides, Succinimides & Phthalimides;Coupling Reagent;N-Substituted Succinimides;Peptide Synthesis;Synthetic Organic Chemistry;Amino ester;Homobifunctional Crosslinker | | Mol File: | 74124-79-1.mol |
| N,N'-Disuccinimidyl carbonate Chemical Properties |
| Melting point | 190 °C (dec.)(lit.) | | Boiling point | 399.41°C (rough estimate) | | density | 1.5670 (rough estimate) | | refractive index | 1.5600 (estimate) | | storage temp. | -20°C | | solubility | Dichloromethane (Slightly, Heated), DMSO | | form | Crystalline Powder | | color | White to slightly yellow | | Water Solubility | Soluble in dimethyl sulfoxide, hot pyridine, acetonitrile and most organic solvents. Insoluble in water. | | BRN | 1499137 | | Stability: | Moisture Sensitive | | InChIKey | PFYXSUNOLOJMDX-UHFFFAOYSA-N | | CAS DataBase Reference | 74124-79-1(CAS DataBase Reference) |
| N,N'-Disuccinimidyl carbonate Usage And Synthesis |
| Chemical Properties | N,N'-Disuccinimidyl carbonate is white to slightly yellow crystalline powder
| | Uses | N,N’Disuccinimidyl Carbonate is a commonly used reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of lig ands to proteins. The coupling reagent property of N,N’Disuucinimidyl Carbonate speeds up coupling process, while reduces the loss of chiral integrity.
| | Uses | N,N'-Disuccinimidyl carbonate is a convenient reagent for the synthesis of N-succinimidyl esters of N-protected amino acids.
| | Uses | N,N'-Disuccinimidyl carbonate is used to prepare cleavable linker succinimide vinylsufonylethyl carbonate for thiol modified-DNA. It serves as a reagent for the synthesis of carbamates. Further, it is used as a coupling reagent as well as in the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate and coupling of ligand to proteins. | | Synthesis Reference(s) | Tetrahedron Letters, 20, p. 4745, 1979 DOI: 10.1016/S0040-4039(01)86699-5 | | General Description | N,N′-Disuccinimidyl carbonate is used for the HPLC determination of amino compounds. |
| N,N'-Disuccinimidyl carbonate Preparation Products And Raw materials |
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