| Diethyl 1,1-cyclobutanedicarboxylate Basic information |
| Product Name: | Diethyl 1,1-cyclobutanedicarboxylate |
| Synonyms: | DIETHYL CYCLOBUTANE-1,1-DICARBOXYLATE;DIETHYL 1,1-CYCLOBUTANEDICARBOXYLATE;1,1-Cyclobutanedicarboxylic Acid 1,1-Diethyl Ester;NSC 9017;1,1-Bis(ethoxycarbonyl)cyclobutane;1,1-Dicarboxylic acid cyclobutane diethylester;1,1-CYCLOBUTANEDICARBOXYLIC ACID DIETHYL ESTER;1,1-DICARBOETHOXYCYCLOBUTANE |
| CAS: | 3779-29-1 |
| MF: | C10H16O4 |
| MW: | 200.23 |
| EINECS: | 223-239-4 |
| Product Categories: | Building Blocks;C10 to C11;Carbonyl Compounds;Chemical Synthesis;Esters;Organic Building Blocks;Pharmaceutical Intermediates;Cyclobutanes & Cyclobutenes;Simple 4-Membered Ring Compounds;Cycloalkanes;Intermediates & Fine Chemicals;Pharmaceuticals |
| Mol File: | 3779-29-1.mol |
| Diethyl 1,1-cyclobutanedicarboxylate Chemical Properties |
| Boiling point | 104-105 °C12 mm Hg(lit.) |
| density | 1.05 g/mL at 20 °C(lit.) |
| refractive index | 1.4360 |
| Fp | 89°C |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | Chloroform, Dichloromethane, Methanol, |
| form | Oil |
| color | Colourless |
| Specific Gravity | 1.05 |
| Water Solubility | Insoluble in water. |
| BRN | 2050195 |
| CAS DataBase Reference | 3779-29-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Diethyl 1,1-cyclobutanedicarboxylate(3779-29-1) |
| EPA Substance Registry System | 1,1-Cyclobutanedicarboxylic acid, diethyl ester (3779-29-1) |
| Safety Information |
| Risk Statements | 36/37/38 |
| Safety Statements | 23-24/25 |
| WGK Germany | 3 |
| TSCA | Yes |
| HS Code | 38220090 |
| MSDS Information |
| Provider | Language |
|---|---|
| SigmaAldrich | English |
| ALFA | English |
| Diethyl 1,1-cyclobutanedicarboxylate Usage And Synthesis |
| Chemical Properties | Colourless Oil |
| Uses | Diethyl 1,1-cyclobutanedicarboxylate is used as a pharmaceutical intermediate. Used as intermediate in the production of Carboplatin. |
| Uses | Diethyl cyclobutane-1,1-dicarboxylate may be used in chemical synthesis studies. |
| Uses | Intermediate in the production of Carboplatin |
| Preparation | The preparation of diethyl 1,1-cyclobutanedicarboxylate is as follows:The major product is tetraethy1 1,1,5,5-pentanetetra-carboxylate II with diethyl malonate. To eliminate this side reaction, II was independently prepared by the addition of hydrogen bromide to diethyl allylmalonate (I) and then cyclized to II by treatment with sodium ethylate. The over-all yield from I is about 50%. |
| Diethyl 1,1-cyclobutanedicarboxylate Preparation Products And Raw materials |
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