Cyclopropanecarbonyl Chloride

CAS No.：4023-34-1

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Cyclopropanecarbonyl Chloride Basic information

Product Name:	Cyclopropanecarbonyl Chloride
Synonyms:	Cyclopropyl Carbonyl Chloride;cyclopropane carbony chloride;CPCCI;Cyclopropylformyl chloride;Cyclopropylcarboxylic acid chloride;Cyclopropanecarboxylic acid chloride,98%;Cyclopropanecarbonylchloride,98%;Cyclopropanecarbonyl
CAS:	4023-34-1
MF:	C4H5ClO
MW:	104.53
EINECS:	223-684-4
Product Categories:	Cyclopropanes;Simple 3-Membered Ring Compounds;Pharmaceutical Intermediates;Acid Halides;Building Blocks;Carbazoles;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;other
Mol File:	4023-34-1.mol

Cyclopropanecarbonyl Chloride Chemical Properties

Melting point	77.5-78.5 °C(Solv: hexane (110-54-3))
Boiling point	119 °C(lit.)
density	1.152 g/mL at 25 °C(lit.)
refractive index	n20/D 1.452(lit.)
Fp	74 °F
storage temp.	2-8°C
form	Liquid
Specific Gravity	1.1520
color	Clear colorless to slightly yellow
Water Solubility	decomposes
Sensitive	Moisture Sensitive
BRN	471286
InChIKey	ZOOSILUVXHVRJE-UHFFFAOYSA-N
CAS DataBase Reference	4023-34-1(CAS DataBase Reference)
NIST Chemistry Reference	Cyclopropanecarboxylic acid chloride(4023-34-1)
EPA Substance Registry System	Cyclopropanecarbonyl chloride (4023-34-1)

Safety Information

Hazard Codes	C,F
Risk Statements	10-34-29-25-36-38
Safety Statements	26-36/37/39-45-8-16
RIDADR	UN 2920 8/PG 2
WGK Germany	3
F	10-21
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29162000
Toxicity	LD50 orally in Rabbit: 200 mg/kg

MSDS Information

Provider	Language
Cyclopropanecarbonyl chloride	English
SigmaAldrich	English
ACROS	English
ALFA	English

Cyclopropanecarbonyl Chloride Usage And Synthesis

Chemical Properties	clear colorless to slightly yellow liquid
Uses	Cyclopropanecarbonyl chloride can be used as an alkylating reagent in the preparation of some chemical building blocks such as formylcyclopropane, cyclopropanecarboxylic acid hydrazide, bis(cyclopropylcarbonyl) peroxide, 1-cyclopropanecarboxamide, 2-cyclopropylcarbonylcyclohexane-1,3-diones and cyclopropyl analog of triazolopiperazine-amides.
Purification Methods	If the IR shows OH bands, then some hydrolysis to the free acid must have occurred. In this case heat with oxalyl chloride at 50o for 2hours or SOCl2 for 30minutes, then evaporate and distil three times using a Dufton column (p 10). Store it in an inert dry atmosphere, preferably in sealed tubes. Strong IRRITANT. If it is free from OH bands, then just distil it in vacuo and store as before. [Jeffrey & Vogel J Chem Soc 1804 1948, Beilstein 9 IV 4.]

Cyclopropanecarbonyl Chloride Preparation Products And Raw materials

Raw materials	Cyclopropanecarboxylic acid
Preparation Products	Fenpropathrin-->TETRAMETHYLALLENE-->Filgotinib-->3-CYCLOPROPYL-3-OXO-PROPIONIC ACID ETHYL ESTER-->Piperazine, 1-(cyclopropylcarbonyl)-, Monohydrochloride-->Cyclopropyl 2-fluorobenzyl ketone-->Cyclopropyl 4-methoxyphenyl ketone-->N-METHOXY-N-METHYLCYCLOPROPANECARBOXAMIDE-->cyclopropanecarboxylic acid (5-bromo-[1,2,4]triazolo[1,5-a]pyridin-2-yl)-amide-->TAK-632

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