Methyl malonyl chloride

CAS No.：37517-81-0

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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Methyl malonyl chloride Basic information

Product Name:	Methyl malonyl chloride
Synonyms:	METHYL 3-CHLORO-3-OXOPROPIONATE;METHYL MALONYL CHLORIDE;METHYL CHLOROFORMYLACETATE;AURORA KA-3053;METHYL 3-CHLORO-3-OXOPROPIONATE,97%;Methyl malonyl chloride 97%;Methyl chloroformylacetate, Methyl malonyl chloride;Methyl Malonyl chloride, 97% 25GR
CAS:	37517-81-0
MF:	C4H5ClO3
MW:	136.53
EINECS:	253-540-6
Product Categories:	Building Blocks;Carbonyl Compounds;Acid Halides;Chemical Synthesis;Organic Building Blocks
Mol File:	37517-81-0.mol

Methyl malonyl chloride Chemical Properties

Boiling point	57-59 °C/12 mmHg (lit.)
density	1.273 g/mL at 25 °C (lit.)
refractive index	n20/D 1.432(lit.)
Fp	176 °F
storage temp.	2-8°C
form	Liquid
pka	9.33±0.46(Predicted)
Specific Gravity	1.275
color	Colorless
Water Solubility	Reacts with water.
Sensitive	Lachrymatory
BRN	1754078
InChIKey	UTBCRHAMJFMIIR-UHFFFAOYSA-N
CAS DataBase Reference	37517-81-0(CAS DataBase Reference)
NIST Chemistry Reference	Methyl malonyl chloride(37517-81-0)

Safety Information

Hazard Codes	C
Risk Statements	34-36/37
Safety Statements	26-36/37/39-45
RIDADR	UN 3265 8/PG 2
WGK Germany	3
F	8-10-19
Hazard Note	Corrosive/Lachrymatory/Keep Cold
HazardClass	8
PackingGroup	II
HS Code	29171900

MSDS Information

Provider	Language
Methyl malonyl chloride	English
SigmaAldrich	English
ACROS	English
ALFA	English

Methyl malonyl chloride Usage And Synthesis

Chemical Properties	Clear light yellow to yellow liquid
Uses	Methyl malonyl chloride is used as pharmaceutical intermediate. Used in anti-cancer drugs.
General Description	Methyl 3-chloro-3-oxopropionate reacts with 4-cyano-1,1′-biphenyl derivatives bearing ω-hydroxyalkyl substituents to yield liquid-crystalline linear malonates and cyanoacetates.

Methyl malonyl chloride Preparation Products And Raw materials

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