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| Glycylglycine Basic information |
| Glycylglycine Chemical Properties |
| Melting point | 220-240 °C (dec.) | | Boiling point | 267.18°C (rough estimate) | | density | 1.5851 (rough estimate) | | vapor pressure | 0.058Pa at 20-50℃ | | refractive index | 1.4880 (estimate) | | storage temp. | Keep in dark place,Inert atmosphere,Room temperature | | solubility | H2O: 1 M at 20 °C, clear, colorless | | pka | 3.139(at 25℃) | | form | Solid | | color | White | | PH | 4.5-6.0 (20℃, 1M in H2O) | | PH Range | 7.5 - 8.9 | | Water Solubility | SOLUBLE IN HOT WATER | | λmax | λ: 260 nm Amax: 0.075λ: 280 nm Amax: 0.072 | | Merck | 14,4503 | | BRN | 1765223 | | Stability: | Stable. Incompatible with strong oxidizing agents. | | InChIKey | YMAWOPBAYDPSLA-UHFFFAOYSA-N | | LogP | -0.92 at 25℃ and pH6 | | CAS DataBase Reference | 556-50-3(CAS DataBase Reference) | | NIST Chemistry Reference | N-Glycylglycine(556-50-3) | | EPA Substance Registry System | Glycylglycine (556-50-3) |
| Hazard Codes | Xi | | Risk Statements | 36 | | Safety Statements | 24/25-26 | | WGK Germany | 3 | | F | 10 | | TSCA | Yes | | HS Code | 29241900 |
| Glycylglycine Usage And Synthesis |
| Chemical Properties | White crystals | | Uses | Glycylglycine is as a buffering reagent and also used in biochemical research. It is the simplest of all dipeptides and is used as a starting template for preparation of more complex peptides. It is also employed as a practical buffer with a buffering range of 7.5 - 8.9 (at 25°C). Valuable agent for experiments investigating peptide transport and absorption. | | Definition | ChEBI: A dipeptide formed from glycine residues. | | Synthesis Reference(s) | Journal of the American Chemical Society, 75, p. 5323, 1953 DOI: 10.1021/ja01117a053 | | Biochem/physiol Actions | Glycine is a non-essential amino acid. Influx of calcium through the cell membrane is mediated by glycine-gated channel. Glycine participates in the synthesis of porphyrins, purine and serine. It also serves as a competitive agonist for glutamate in binding to the NMDA (N-methyl-D-aspartate) receptors. Glycine synthesis might be increased in rapidly proliferating cancer cells, due to increased demand for the amino acid. Diglycine is known to catalyze the formation of homo- and hetero dipeptides more efficiently than glycine. | | Purification Methods | Crystallise glycylglycine from aqueous 50% EtOH or water at 50-60o by addition of EtOH. Dry it at 110o. It sublimes at 190-200o/0.3mm with 30% recovery [Gross & Gradsky J Am Chem Soc 77 1678 1955, King J Am Chem Soc 79 6153 1957]. [Beilstein 4 IV 2459.] |
| Glycylglycine Preparation Products And Raw materials |
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