6-Chloroguanine

6-Chloroguanine
  • CAS No.:10310-21-1
Other grades of this product :
6-Chloroguanine Basic information
Description
Product Name:6-Chloroguanine
Synonyms:Clofarabine Impurity 3;AURORA KA-689;2-amino-6-chloro-purin;2-AMINO-6-CHLOROPURINE;6-CHLORO-2-AMINOPURINE;6-CHLORO-9H-PURIN-2-YLAMINE;6-CHLOROGUANINE;6-Chloro-7H-purin-2-ylamine
CAS:10310-21-1
MF:C5H4ClN5
MW:169.57
EINECS:233-686-7
Product Categories:Biochemistry;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Nucleic acids;Bases & Related Reagents;Nucleotides;FINE Chemical & INTERMEDIATES;Starting Raw Materials & Intermediates;Miscellaneous Biochemicals;Amines;Purine;Nucleotides and Nucleosides;Purines;Fused Ring Systems;Aromatics;Heterocycles;Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks
Mol File:10310-21-1.mol
6-Chloroguanine Chemical Properties
Melting point >300 °C (lit.)
Boiling point 279.76°C (rough estimate)
density 1.4937 (rough estimate)
refractive index 1.6110 (estimate)
storage temp. 2-8°C
solubility Solubility in 1mol/L NaOH; very faint turbidity.
form Powder
pka6.65±0.20(Predicted)
color White to yellow
Water Solubility 1.7 g/L (20 ºC)
BRN 9626
InChIKeyRYYIULNRIVUMTQ-UHFFFAOYSA-N
CAS DataBase Reference10310-21-1(CAS DataBase Reference)
EPA Substance Registry System6-Chloro-2-aminopurine (10310-21-1)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 20/21/22-36/37/38
Safety Statements 22-24/25-36-26
WGK Germany 3
RTECS UO7502000
10
Hazard Note Irritant/Keep Cold
HazardClass IRRITANT, KEEP COLD
HS Code 29339900
MSDS Information
ProviderLanguage
6-Chloroguanine English
ACROS English
SigmaAldrich English
ALFA English
6-Chloroguanine Usage And Synthesis
Description6-Chloroguanine, also be known as 2-Amino-6-chloropurine may be used in the enzymatic synthesis of 2′-deoxyguanosine, 9-alkyl purines (R)and (S)-N(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases. It is also useful during the synthesis of guanine.
Description2-Amino-6-chloropurine is a precursor in the synthesis of nucleoside analogs with antiviral activity against Epstein-Barr virus (EBV) and human herpes virus 6 (HHV-6).
Chemical Propertieswhite to light yellow crystal powder
Uses2-Amino-6-chloropurine may be used:
  • in the enzymatic synthesis of 2′-deoxyguanosine
  • in the synthesis of 9-alkyl purines
  • in the synthesis of (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases
Uses2-Amino-6-chloropurine finds its uses in the enzymatic synthesis of 2?-deoxyguanosine, 9-alkyl purines and (R)- and (S)-N-(2-phosphonomethoxypropyl) derivatives of purine and pyrimidine bases.
DefinitionChEBI: An organochlorine compound that is 7H-purin-2-amine substituted by a chloro group at position 6.
General Description2-Amino-6-chloropurine is a 6-substituted purine. Tautomeric purine forms of 2-amino-6-chloropurine were investigated by vibrational spectroscopy and quantum chemical method.

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