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| 2-CHLORO-4-PHENYLQUINAZOLINE Basic information | | Uses |
| 2-CHLORO-4-PHENYLQUINAZOLINE Chemical Properties |
| Melting point | 113.0 to 117.0 °C | | Boiling point | 347.4±30.0 °C(Predicted) | | density | 1.285±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | powder to crystal | | pka | 0.24±0.30(Predicted) | | color | White to Orange to Green |
| 2-CHLORO-4-PHENYLQUINAZOLINE Usage And Synthesis |
| Uses | 2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators. | | Uses | 2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators. | | Uses | 2-CHLORO-4-PHENYLQUINAZOLINE can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process. | | Synthesis | A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ° C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield). |
| 2-CHLORO-4-PHENYLQUINAZOLINE Preparation Products And Raw materials |
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