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| 1,3-Benzodioxole Basic information |
| Product Name: | 1,3-Benzodioxole | | Synonyms: | 1,2-Methylenedioxybenzene (MDB);1,2- Methylenetwophenoxy;Anti-ABR (C-terminal) antibody produced in rabbit;FLJ45954;1,2-Methylenedioxybenzene 1,3-Benzodioxole;1,2-methylenedioxy-benzen;1,3-Dioxaindan;1,3-Dioxindan | | CAS: | 274-09-9 | | MF: | C7H6O2 | | MW: | 122.12 | | EINECS: | 205-992-0 | | Product Categories: | Aromatic Ethers;274-09-9 | | Mol File: | 274-09-9.mol |
| 1,3-Benzodioxole Chemical Properties |
| Melting point | -18 °C | | Boiling point | 172-173 °C(lit.) | | density | 1.064 g/mL at 25 °C(lit.) | | vapor pressure | 12 mm Hg ( 25 °C) | | refractive index | n20/D 1.539(lit.) | | Fp | 131 °F | | storage temp. | Inert atmosphere,Room Temperature | | solubility | 2g/l | | form | Powder | | color | Yellow to orange to brown | | Water Solubility | 0.2 g/100 mL (25 ºC) | | BRN | 115506 | | InChIKey | FTNJQNQLEGKTGD-UHFFFAOYSA-N | | LogP | 2.08 | | CAS DataBase Reference | 274-09-9(CAS DataBase Reference) | | NIST Chemistry Reference | 1,3-Benzodioxole(274-09-9) | | EPA Substance Registry System | 1,3-Benzodioxole (274-09-9) |
| 1,3-Benzodioxole Usage And Synthesis |
| Description | 1,3-Benzodioxole, widely found in plant products, has shown potent antioxidant and antibacterial activities. It has recently been reported that 1,3-benzodioxole derivatives possess cytotoxic activity against several human tumor cell lines, including human colon carcinoma cells and multidrug-resistant nasopharyngeal carcinoma cells. No cytotoxic effects were noticed at a concentration of 10-4 M. | | Chemical Properties | clear colourless to light yellow liquid. Insoluble in acids. | | Uses | 1,3-Benzodioxole is useful in gemological stimulant detection. It is also used as a precursor for perfumes, photo initiators, agrochemicals and pharmaceuticals. 1,3-benzodimine is an intermediate for the synthesis of the drugs oxolinic acid, cinoxacin and miloxacin. | | Definition | ChEBI: 1,3-benzodioxole is a benzodioxole consisting of a benzene ring substituted by a the methylenedioxy group. | | Application | 1,3-Benzodioxole belong to methylenedioxyphenyl (MDP) compounds that regulate cytochrome P 450-dependent drug oxidation, which is important in the process of eliminating drugs from the body. a hydrogen abstraction process can take place from the methylene-bridgea carbon of the benzodioxole compound and form a methylenedioxybenzene radical. It is therefore highly likely that 1,3-benzodioxole could serve as hydrogen donor for a CQ-based system initiating the photopolymerization of dental composite resin. In addition, 1,3-benzodioxole is an important organic intermediate (building block) to synthetize substituted methylenedioxybenzene products. | | General Description | Supersonic jet fluorescence spectra of 1,3-benzodioxole has been studied. The far-infrared spectrum of the vapour of 1,3-benzodioxole has been reported. The electronic absorption spectra and the laser-induced fluorescence spectra of supersonic-jet-cooled 1,3-benzodioxole molecules has been investigated. |
| 1,3-Benzodioxole Preparation Products And Raw materials |
| Raw materials | Ethanol-->Sodium hydroxide-->Diethyl ether-->Acetone-->FUMING SULFURIC ACID-->Dimethyl sulfoxide-->Calcium chloride-->Paraformaldehyde-->Catechol-->1-IODO-3,4-METHYLENEDIOXYBENZENE | | Preparation Products | Ethyl vanillin-->Piperonyl aldehyde-->4-NITROCATECHOL-->3,4-METHYLENEDIOXYPHENYL ISOTHIOCYANATE-->3,4-(Methylenedioxy)phenylacetonitrile-->PIPERONYL FORMALDEHYDE-->1,2-(Methylenedioxy)-4-nitrobenzene-->Piperonyl chloride-->HOMOPIPERONYLAMINE-->(+/-)-1-(1,3-Benzodioxol-5-yl)-2-broMo-1-pentanone-->5-CHLORO-1,3-BENZODIOXOLE-->N,N,N',N'-TETRAETHYLMETHYLENEDIAMINE-->3,4-(METHYLENEDIOXY)BUTYROPHENONE-->1,3-BENZODIOXOLE-4-CARBOXYLIC ACID |
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