Product

2,4'-Dibromoacetophenone

CAS No.：99-73-0

Other grades of this product :

2,4'-Dibromoacetophenone Basic information

Product Name:	2,4'-Dibromoacetophenone
Synonyms:	P-BROMOPHENACYL BROMIDE;PBPB;OMEGA-BROMOACETOPHENONE;bromomethyl4-bromophenylketone;bromomethylp-bromophenylketone;omega,4-dibromoacetophenone;p,alpha-dibromoacetophenone;p-bromophenacyl-8
CAS:	99-73-0
MF:	C8H6Br2O
MW:	277.94
EINECS:	202-783-6
Product Categories:	Other enzyme inhibitors and activators;Aromatic Acetophenones & Derivatives (substituted);Carboxyl Group Labeling Reagents for HPLC;UV Detection (HPLC Labeling Reagents);Analytical Chemistry;HPLC Labeling Reagents;Adehydes, Acetals & Ketones;Bromine Compounds;Analytical Reagents;Analytical/Chromatography;Bioactive Small Molecules;Biochemicals and Reagents;Building Blocks;C7 to C8;Carbonyl Compounds;Cell Biology;Chemical Synthesis;D-DIF;Derivatization agents;Derivatization Reagents;Derivatization Reagents HPLC;Fluorescence;Halogenated;Ketones;Luminescent Compounds/Detection;Organic Building Blocks
Mol File:	99-73-0.mol

2,4'-Dibromoacetophenone Chemical Properties

Melting point	108-110 °C(lit.)
Boiling point	1415°C/760mm
density	1.7855 (rough estimate)
refractive index	1.5560 (estimate)
storage temp.	Store below +30°C.
form	Crystalline Solid
color	Slightly yellow to beige
Water Solubility	Soluble in dimethyl sulfoxide (5 mg/ml), methanol (20 mg/ml), toluene and ethanol. Insoluble in water.
Sensitive	Lachrymatory
Merck	14,1427
BRN	607604
Stability:	Stable. Incompatible with strong bases, strong reducing agents, strong oxidizing agents.
InChIKey	FKJSFKCZZIXQIP-UHFFFAOYSA-N
CAS DataBase Reference	99-73-0(CAS DataBase Reference)
EPA Substance Registry System	Ethanone, 2-bromo-1-(4-bromophenyl)- (99-73-0)

Safety Information

Hazard Codes	C
Risk Statements	34
Safety Statements	26-36/37/39-45
RIDADR	UN 3261 8/PG 2
WGK Germany	2
RTECS	AM6950000
F	19-21
Hazard Note	Corrosive/Lachrymatory
TSCA	T
HazardClass	8
PackingGroup	III
HS Code	29147090

MSDS Information

Provider	Language
2,4'-Dibromoacetophenone	English
SigmaAldrich	English
ACROS	English
ALFA	English

2,4'-Dibromoacetophenone Usage And Synthesis

Chemical Properties	2,4'-Dibromoacetophenone is off-white crystals or powder
Uses	Undergoes condensation reactions with aldehydes in the presence of SnCl21 or SmI32 to afford α,β-unsaturated ketones. Also useful in the esterification of carboxylic acids.3
Uses	Identification of carboxylic acids.
Uses	2,4'-Dibromoacetophenone is used as a reagent for analysis of fatty acids by HPLC as 4-bromophenacyl esters, for use in the protection of phenols and carboxylic acids. It undergoes condensation reactions with aldehydes in the presence of SnCl2 or SmI3 to afford α,β-unsaturated ketones. It is also useful in the esterification of carboxylic acids.
General Description	A phenyl α-bromomethyl ketone compound that acts as a cell-permeable, and non-ATP competitive inhibitor of GSK-3β (IC₅₀ = 0.5 μM). This reactive alkylating agent is selective towards GSK-3β and does not affect PKA activity even at concentrations as high as 100 μM.
Biochem/physiol Actions	Cell permeable: yes
Purification Methods	Crystallise the bromide from EtOH (ca 8mL/g). [Beilstein 7 IV 652.]

2,4'-Dibromoacetophenone Preparation Products And Raw materials

Raw materials	4'-Bromoacetophenone
Preparation Products	3-(4-BROMOPHENYL)ISOXAZOL-5-AMINE-->4-(4-BROMO-PHENYL)-1H-IMIDAZOLE-->2-(4-BROMOBENZOYL)-1-BENZOFURAN-5-CARBALDEHYDE-->2-(4-bromophenyl)morpholine-->2-Amino-4'-bromoacetophenone-->1-(4-bromophenyl)-2-chloroethan-1-one

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873