| Tetraethyl orthocarbonate Basic information |
| Product Name: | Tetraethyl orthocarbonate |
| Synonyms: | ORTHOCARBONIC ACID TETRAETHYL ESTER;TETRAETHOXYMETHANE;TETRAETHYL ORTHOCARBONATE;1-(Triethoxymethoxy)ethane;1,1’,1’’,1’’’-[methanetetrayltetrakis(oxy)]tetrakis-ethan;Tetraehtylorthocarbonate;[methanetetrayltetrakis(oxy)]tetrakis-;Ethane, 1,1‘,1‘‘,1‘‘‘- |
| CAS: | 78-09-1 |
| MF: | C9H20O4 |
| MW: | 192.25 |
| EINECS: | 201-082-2 |
| Product Categories: | Acetals/Ketals/Ortho Esters;Organic Building Blocks;Oxygen Compounds |
| Mol File: | 78-09-1.mol |
| Tetraethyl orthocarbonate Chemical Properties |
| Melting point | 222 °C |
| Boiling point | 159 °C (lit.) |
| density | 0.919 g/mL at 25 °C (lit.) |
| refractive index | n |
| Fp | 127 °F |
| storage temp. | Inert atmosphere,Room Temperature |
| form | clear liquid |
| color | Colorless to Almost colorless |
| Specific Gravity | 0.919 |
| Water Solubility | Insoluble |
| Sensitive | Moisture Sensitive |
| BRN | 1747401 |
| CAS DataBase Reference | 78-09-1(CAS DataBase Reference) |
| NIST Chemistry Reference | Ethane, 1,1',1'',1'''-[methanetetrayltetrakis(oxy)]tetrakis-(78-09-1) |
| EPA Substance Registry System | Ethane, 1,1',1'',1'''-[methanetetrayltetrakis(oxy)]tetrakis- (78-09-1) |
| Safety Information |
| Hazard Codes | Xi,F |
| Risk Statements | 10-36/37/38 |
| Safety Statements | 37/39-26-16-36-24/25 |
| RIDADR | UN 3272 3/PG 3 |
| WGK Germany | 3 |
| F | 21 |
| HazardClass | 3 |
| PackingGroup | III |
| HS Code | 29209010 |
| MSDS Information |
| Provider | Language |
|---|---|
| Tetraethoxymethane | English |
| ACROS | English |
| SigmaAldrich | English |
| ALFA | English |
| Tetraethyl orthocarbonate Usage And Synthesis |
| Chemical Properties | clear colorless liquid |
| Uses | Tetraethyl Orthocarbonate is used in the synthesis of chemokine receptor-5 inhibitors against HIV-1, benzobisoxazoles and in the preparation of organic semiconductors. It is also employed in the synthesis of 2,7-dimethylene-1,4,6,9-tetraoxaspiro[4,4]nonane and in the synthesis of cross linked poly(orthocarbonate)s used as organic solvent absorbent. |
| Purification Methods | Likely impurities are hydrolysis products. Shake the orthocarbonate with brine (saturated NaCl, dilute with a little Et2O if amount of material is small) and dry (MgSO4). The organic layer is filtered off and evaporated, and the residue is distilled through a helices packed fractionating column with a total reflux partial take-off head. All distillations can be done at atmospheric pressure in an inert atmosphere (e.g. N2). [Roberts & McMahon Org Synth Coll Vol IV 457 1963, Connolly & Dyson J Chem Soc 828 1937, Tieckelmann & Post J Org Chem 13 266 1948, for review see Kantlehner et al. Justus Liebigs Ann Chem 507 207 1982, Beilstein 3 IV 6.] |
| Tetraethyl orthocarbonate Preparation Products And Raw materials |
| Preparation Products | Prednicarbate-->Ethyl-2-Ethoxy-1-[[(2'-Cyanobiphenyl-4-yl) Methyl] Benzimidazole]-7-Carboxylate-->1,2,3-TRIPHENYLGUANIDINE-->Tetramethoxymethane-->3,5-DIMETHYL-4-HEPTANONE |
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