Difenoconazole

Difenoconazole
  • CAS No.:119446-68-3

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  1. This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
  2. This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
  3. The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.
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Difenoconazole Basic information
Product Name:Difenoconazole
Synonyms:1-((2-(2-chloro-4-(4-chlorophenoxy)phenyl)-4-methyl-1,3-dioxolan-2-yl)methyl)-1h-1,2,4-triazole;DIFENOCONAZOL;DIFENOCONAZOLE;DIVIDEND;1H-1,2,4-Triazole, 1-2-2-chloro-4-(4-chlorophenoxy)phenyl-4-methyl-1,3-dioxolan-2-ylmethyl-;difenoconazole (bsi,draft e-iso);3-Chloro-4-4-methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-2-y14-chlorophenylether;Difenoconazole E.C.
CAS:119446-68-3
MF:C19H17Cl2N3O3
MW:406.26
EINECS:
Product Categories:Alpha sort;ConazolesPesticides&Metabolites;D;DAlphabetic;DID - DIN;Fungicides;Pesticides;119446-68-3
Mol File:119446-68-3.mol
Difenoconazole Chemical Properties
Melting point 76°C
Boiling point 220°C
density 1.4916 (rough estimate)
vapor pressure 3.3 x l0-8 Pa (25 °C)
refractive index 1.6140 (estimate)
storage temp. Keep in dark place,Sealed in dry,2-8°C
form neat
pka2.94±0.12(Predicted)
Water Solubility 3.3 mg/L (20 ºC)
Merck 13,3160
BRN 9073356
CAS DataBase Reference119446-68-3(CAS DataBase Reference)
NIST Chemistry ReferenceDifenoconazole(119446-68-3)
EPA Substance Registry SystemDifenoconazole (119446-68-3)
Safety Information
Hazard Codes Xn,N
Risk Statements 22-41-43-50-20/22
Safety Statements 26-36/37/39-61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
RTECS XZ4380000
Hazardous Substances Data119446-68-3(Hazardous Substances Data)
ToxicityLD50 in rats (mg/kg): 1453 orally; in rabbits: >2010 dermally (Ruess)
MSDS Information
ProviderLanguage
Difenoconazole English
Difenoconazole Usage And Synthesis
DescriptionDifenoconazole is a kind of triazole-type fungicide. It is a broad-spectrum triazole fungicide. It takes effect through acting as the inhibitor of sterol 14α-demethylase, blocking the biosynthesis of sterol. Through inhibiting the sterol biosynthesis process, it inhibits the mycelia growth and germination of pathogens by spores, ultimately suppressing the proliferation of fungi. Difenoconazole has been extensively used in a wide range of crops in many countries due to its ability to control various fungal diseases. It is also one of the most important and widely-used pesticides for disease control in rice.
UsesAgricultural fungicide.
UsesPestanal is an fungicide that exhibits a broad spectrum of activities against a wide variety of fungi including members of the Aschomycetes, Basidomycetes and Deuteromycetes families.
UsesDifenoconazole is a fungicide with broad-range activity, protecting yield and quality by foliar application or seed treatment. It provides long-lasting and curative activity against Ascomycetes, Basidiomycetes and Deuteromycetes. It is used against disease complexes in grapes, pome fruit, stone fruit, potatoes, sugar beet, oilseed rape, banana, ornamentals and various vegetable crops. It is also used as a seed treatment against a range of pathogens in wheat and barley.
DefinitionChEBI: A member of the class of dioxolanes that is 1,3-dioxolane substituted at position 2 by 2-chloro-4-(4-chlorophenoxy)phenyl and 1,2,4-triazol-1-ylmethyl groups. A broad spectrum fungicide with novel broad-range activity used as a spray or seed treatment. It is moderately toxic to humans, mammals, birds and most aquatic organisms.
Agricultural UsesFungicide: For suppression of fungi diseases in crops and seeds.
Trade nameCGA 169374®; DIVIDEND®; DIVIDEND® EXTREME FUNGICIDE; HELIX®; SCORE®; TECHNICAL CGA-169374®
Metabolic pathwayThere is limited published information on the metabolism of difenoconazole. It is slowly dissipated in soils, and metabolism in plants involves rupture of the triazole linkage or oxidation of the phenyl ring followed by conjugation.
DegradationDifenoconazole is stable to hydrolysis and is thermally stable to 150 °C. DT50 of difenocoazole in natural sunlight was 145 days.
ReferencesKwok, Iris M‐Y., and R. Thomas Loeffler. "The biochemical mode of action of some newer azole fungicides." Pest Management Science 39.1 (1993): 1-11. Wang, K., J. X. Wu, and H. Y. Zhang. "Dissipation of difenoconazole in rice, paddy soil, and paddy water under field conditions." Ecotoxicology and environmental safety 86 (2012): 111-115.
Difenoconazole Preparation Products And Raw materials

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