5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde

CAS No.：881674-56-2

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5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Basic information

Product Name:	5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde
Synonyms:	1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-;5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde;5-(2-Fluorophenyl)-1H-pyrrole-3-carbal...;5-(2-Fluorophenyl)-1H-pyrrole-3-carboxaldehyde;1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-;TAK438 Impurity 54;1H-Pyrrole-3-carboxaldehyde, 5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde;TAK-438( Vonoprazan fumarate) intermediate 3
CAS:	881674-56-2
MF:	C11H8FNO
MW:	189.19
EINECS:	809-913-6
Product Categories:	Vonoprazan;Pharmaceutical Intermediates
Mol File:	881674-56-2.mol

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Chemical Properties

Melting point	133 °C
Boiling point	370.6±32.0 °C(Predicted)
density	1.270±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	14.77±0.50(Predicted)
color	Light Brown to Brown
Stability:	Hygroscopic

Safety Information

HS Code

2933998090

MSDS Information

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Usage And Synthesis

Chemical Properties	Light orange to Yellow to Green powder to crystal.
Uses	5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde acts as a reagent in the synthetic preparation of novel pyrrole derivatives as potassium-competitive acid blocker (P-CAB).
Application	5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde is a potassium ion-competitive acid blocker used in therapy Acid-related diseases, gastric ulcer, duodenal ulcer, reflux esophagitis, etc.
Preparation	Synthesis of 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde: Using pyrrole as raw material, after being protected by N-alkylation of triisopropylsilyl chloride, it is then reacted with Vilsmeier reagent to obtain 1H-Pyrrole-3-carbaldehyde, which is then purified by N-bromosuccinimide (NBS) bromination and 2-fluorophenylboronic acid for Suzuki coupling reaction to obtain crude 5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde, which was purified with toluene. The total yield was 35.5%.

5-(2-Fluorophenyl)-1H-pyrrole-3-carbaldehyde Preparation Products And Raw materials

Raw materials	2-[2-(2-Fluorophenyl)-2-oxoethyl]propanedinitrile-->5-(2-fluorophenyl)-1H-pyrrole-3-carbonitrile
Preparation Products	4-fluoro-5-(2-fluorophenyl)-1H-pyrrole-3-carbaldehyde

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