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| (Bromomethyl)cyclobutane Basic information |
| Product Name: | (Bromomethyl)cyclobutane | | Synonyms: | CYCLOBUTYLMETHYL BROMIDE;(BROMOMETHYL)CYCLOBUTANE;(Bromomethyl)codobutane;Cyclobutane, (bromomethyl)-;(BROMOMETHYL)CYCLOBUTANE 99%;(Bromomethyl)cyclobu;Cyclobuty-1-Methyl broMide;CYCLOBUTYL METHYL BROMIDE FOR SYNTHESIS | | CAS: | 17247-58-4 | | MF: | C5H9Br | | MW: | 149.03 | | EINECS: | 700-027-4 | | Product Categories: | Cycloalkanes | | Mol File: | 17247-58-4.mol |
| (Bromomethyl)cyclobutane Chemical Properties |
| Boiling point | 123-124 °C(lit.) | | density | 1.326 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.48(lit.) | | Fp | 97 °F | | storage temp. | Inert atmosphere,2-8°C | | form | Liquid | | Specific Gravity | 1.326 | | color | Clear colorless | | Water Solubility | 80mg/L at 20℃ | | InChIKey | FLHFTXCMKFVKRP-UHFFFAOYSA-N | | CAS DataBase Reference | 17247-58-4(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 10-36/37/38 | | Safety Statements | 16-26-36 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 3 | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29038900 |
| (Bromomethyl)cyclobutane Usage And Synthesis |
| Chemical Properties | clear colorless liquid | | Uses | (Bromomethyl)cyclobutane may be used in the synthesis of racemic 3-cyclobutylalanine and 17-(cyclobutylmethyl)morphinan-3-ol (butorphan). | | Preparation | The preparation of (Bromomethyl)cyclobutane is as follows:Into a clean, dry reactor equipped with a stirrer and under nitrogen are successively loaded 5.4 kg of DMF (5.1 eqV) and then 4.53 kg of triphenylphosphite. 2.34 kg of bromine is then introduced while maintaining the temperature at less than 12°C. The stirring speed is regulated according to the fluidity of the reaction medium.10065] The set point of the jacket is then adjusted to -12°C. and then 1.120 kg of cyclobutylmethanol is introduced in such a way as not to exceed a temperature of -5° C. At the end of the addition the whole is allowed to return slowly to room temperature. After distillation and washing, the final product 2b (mass 1.529 kg) having a GC relative purity of 98.3% is obtained with a yield of 78%. | | General Description | (Bromomethyl)cyclobutane (bromomethyl-cyclobutane) is an aryl fluorinated building block. Its reaction with various hydroxychromen-4-one derivatives in the presence of anhydrous K2CO3/dry acetone and Bu4N+I- (PTC) has been investigated. |
| (Bromomethyl)cyclobutane Preparation Products And Raw materials |
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