Z-DEVD-FMK

CAS No.：210344-95-9

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Other grades of this product :

Z-DEVD-FMK Basic information

Product Name:	Z-DEVD-FMK
Synonyms:	Z-ASP-GLU-VAL-ASP-FLUOROMETHYLKETONE;Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-CH2F;Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FLUOROMETHYLKETONE;Z-ASP(OME)-GLU(OME)-VAL-ASP(OME)-FMK;Z-ASP(OME)-GLU(OME)-VAL-DL-ASP(OME)-FLUOROMETHYLKETONE;Z-DEVD-FLUOROMETHYLKETONE;Z-DEVD-FMK;Z-D(OME)E(OME)VD(OME) FLUOROMETHYLKETONE
CAS:	210344-95-9
MF:	C30H41FN4O12
MW:	668.66
EINECS:
Product Categories:	Inhibitors;Apoptosis;Caspases/Apoptosis;peptide;peptides;API;Caspase/Related Products;Pepetides
Mol File:	Mol File

Z-DEVD-FMK Chemical Properties

Boiling point	914.2±65.0 °C(Predicted)
density	1.260±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Store in freezer, under -20°C
solubility	DMSO/DMF: ≥20 mM
form	White to slightly brown solid
pka	10.26±0.46(Predicted)

Safety Information

WGK Germany

MSDS Information

Provider	Language
SigmaAldrich	English

Z-DEVD-FMK Usage And Synthesis

Uses	Z-DEVD-FMK is an irrversible caspase-3 inhibitor used as an anaesthetic agent. In addition, it is proposed to increase the longevity of platelet storage.
General Description	A potent, cell-permeable, and irreversible inhibitor of caspase-3 as well as caspase-6, caspase-7, caspase-8, and caspase-10. When using with purified native or recombinant enzyme, pretreatment with an esterase is required. A 5 mM (250 μg/75 μl) solution of Z-DEVD-FMK (Cat. No. 264156) in DMSO is also available.
Biological Activity	Cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo .
Biochem/physiol Actions	Cell permeable: yes
references	1. garcia-calvo m, peterson ep, leiting b, ruel r, nicholson dw, thornberry na (1998) inhibition of human caspases by peptidebased and macromolecular inhibitors. j biol chem 273:32608–32613 2. thornberry na, rano ta, peterson ep, rasper dm, timkey t, garcia-calvo m, houtzager vm, nordstrom pa, roy s, vaillancourt jp, chapman kt, nicholson dw (1997) a combinatorial approach defines specificities of members of the caspase family and granzyme b. functional relationships established for key mediators of apoptosis. j biol chem 272:17907–17911 3. yakovlev ag, knoblach sm, fan l, fox gb, goodnight r, faden ai (1997) activation of cpp32-like caspases contributes to neuronal apoptosis and neurological dysfunction after traumatic brain injury. j neurosci 17:7415–7424 4. clark rs, kochanek pm, watkins sc, chen m, dixon ce, seidberg na, melick j, loeffert je, nathaniel pd, jin kl, graham sh (2000) caspase-3 mediated neuronal death after traumatic brain injury in rats. j neurochem 74:740–753 5. s. m. knoblach, d. a. alroy et al, caspase inhibitor z-devd-fmk attenuates calpain and necrotic cell death in vitro and after traumatic brain injury, journal of cerebral blood flow & metabolism 24:1119–1132.

Z-DEVD-FMK Preparation Products And Raw materials

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873