Thiazole-5-carboxaldehyde

CAS No.：1003-32-3

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
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Thiazole-5-carboxaldehyde Basic information

Product Name:	Thiazole-5-carboxaldehyde
Synonyms:	5-THIAZOLECARBOXALDEHYDE;THIAZOLE-5-CARBALDEHYDE;THIAZOLE-5-CARBOXALDEHYDE;1,3-Thiazole-5-carboxaldehyde;Thiazole-5-carboxyaldehyde;5-THIAOLECARBOXALDEHYDE;5-Formylthiazole;Thiazole-5-carboxaldehyde ,97%
CAS:	1003-32-3
MF:	C4H3NOS
MW:	113.14
EINECS:
Product Categories:	Building Blocks;Thiazole;Aldehydes;blocks;Building Blocks;Heterocyclic Building Blocks;Thiazoles
Mol File:	1003-32-3.mol

Thiazole-5-carboxaldehyde Chemical Properties

Melting point	229 °C (decomp)
Boiling point	92-94 °C/16 mmHg
density	1.304 g/mL at 25 °C
refractive index	1.5874
Fp	98 °C
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	0.94±0.10(Predicted)
form	powder to lump to clear liquid
color	White or Colorless to Yellow
InChIKey	ZXRLWHGLEJGMNO-UHFFFAOYSA-N
CAS DataBase Reference	1003-32-3(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-43-36-22
Safety Statements	26-36/37/39-36/37
WGK Germany	3
HazardClass	IRRITANT
HS Code	29341000

MSDS Information

Thiazole-5-carboxaldehyde Usage And Synthesis

Chemical Properties	White to brown liquid or solid
Uses	Thiazole-5-carboxaldehyde is used in the synthesis of imidazoles with cardiomyocyte proliferation activity for heart disease treatments.
Synthesis Reference(s)	Synthetic Communications, 25, p. 4081, 1995 DOI: 10.1080/00397919508011485Synthesis, p. 998, 1987 DOI: 10.1055/s-1987-28146
Purification Methods	Dry the aldehyde over Na2SO4 and fractionate it in a vacuum. The 2,4-dinitrophenylhydrazone forms red crystals from MeOH with m 238-240o, and the semicarbazone has m 210-212o (from MeOH). [Erne et al. Helv Chim Acta 34 148 1951, Beilstein 27 III/IV 2615.]

Thiazole-5-carboxaldehyde Preparation Products And Raw materials

Raw materials

Methanol-->Dichloromethane-->N,N-Dimethylformamide-->PETROLEUM ETHER-->Sodium sulfate-->Sodium bicarbonate-->Hydrogen-->Sodium acetate trihydrate-->Phosphorus oxybromide-->Magnesium sulfate heptahydrate-->HEAVY DISTILLATE-->2,4-Thiazolidinedione

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