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| 3-Amino-1,2-propanediol Basic information |
| 3-Amino-1,2-propanediol Chemical Properties |
| Melting point | 55-57 °C | | Boiling point | 264-265 °C739 mm Hg(lit.) | | density | 1.175 g/mL at 25 °C(lit.) | | vapor pressure | <1 hPa (20 °C) | | refractive index | n20/D 1.492(lit.) | | Fp | >230 °F | | storage temp. | Store below +30°C. | | solubility | >1000g/l soluble | | form | liquid (highly viscous) | | pka | 12.11±0.35(Predicted) | | color | Clear colorless to pale yellow | | Specific Gravity | 1.175 | | PH | 11 (100g/l, H2O, 20℃) | | Water Solubility | soluble | | Sensitive | Hygroscopic | | BRN | 1719121 | | InChIKey | KQIGMPWTAHJUMN-UHFFFAOYSA-N | | CAS DataBase Reference | 616-30-8(CAS DataBase Reference) | | NIST Chemistry Reference | 3-Amino-1,2-propanediol(616-30-8) | | EPA Substance Registry System | 1,2-Propanediol, 3-amino- (616-30-8) |
| Hazard Codes | C,Xi | | Risk Statements | 34-36/37/38 | | Safety Statements | 26-36/37/39-45-36 | | RIDADR | UN 2735 8/PG 2 | | WGK Germany | 2 | | RTECS | TY2800000 | | F | 10-21 | | Hazard Note | Corrosive | | TSCA | Yes | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29221980 | | Toxicity | LD50 orally in Rabbit: 7500 mg/kg |
| 3-Amino-1,2-propanediol Usage And Synthesis |
| Description | 3-Amino-1,2-propanediol (APD) is a calcium metabolism regulator useful in the treatment of Paget's disease, tumor-induced hypercalcemia and other bone disorders involving increased osteoclastic activity. | | Chemical Properties | 3-Amino-1,2-propanediol is a very viscous transparent colorless to pale yellow liquid with a melting point of 55-57 °C and a boiling point of 264-265 °C. The density at 25 °C is 1.175 g/mL. soluble in water. | | Originator | Henkel (W. Germany) | | Uses | 3-Amino-1,2-propanediol is used in the preparation of iohexol, which is a X-CT non-ionic contrast medium. It acts as a starting material in the production of specialty materials. | | Application | (±)-3-Amino-1,2-propanediol is used as a reactant in the synthesis of lipid-like delivery molecules(lipidoids) for RNA interference (RNAi) therapeutics. It is also used in the synthesis of the bioactive template to prepare cationic α-helical polypeptides and various cationic polymers for gene delivery. | | Preparation | 3-Amino-1,2-propanediol is synthesized by reacting 3-chloro-1,2-propanediol (CPD) with ammonia in alkaline environment by adding sodium hydroxide. Afterwards, the product undergoes a series of purification steps. | | Brand name | Aminomux | | Safety Profile | Poison by intraperitoneal route.Moderately toxic by ingestion. When heated todecomposition it emits toxic fumes of NOx. |
| 3-Amino-1,2-propanediol Preparation Products And Raw materials |
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