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| 2-METHYLACETANILIDE Basic information |
| Product Name: | 2-METHYLACETANILIDE | | Synonyms: | Acetamide,N-(2-methylphenyl)-;Acet-o-toluidide;N-Acetyl-o-toluidine
2'-Methylacetanilide;Prilocaine Impurity 16;2-Methylacetaniline;o-Acetotoluidine;n-(2-methylphenyl)-acetamid;N-(2-Methylphenyl)acetamide | | CAS: | 120-66-1 | | MF: | C9H11NO | | MW: | 149.19 | | EINECS: | 204-414-4 | | Product Categories: | Anilines, Amides & Amines | | Mol File: | 120-66-1.mol |
| 2-METHYLACETANILIDE Chemical Properties |
| Melting point | 109-112 °C | | Boiling point | 296 °C | | density | 1.16 | | refractive index | 1.5279 (estimate) | | Fp | 296°C | | storage temp. | Sealed in dry,Room Temperature | | solubility | It is slightly soluble in acetone, chloroform, toluene, benzene. | | form | Solid | | pka | 15.13±0.70(Predicted) | | color | Needles | | Merck | 14,74 | | BRN | 2207054 | | CAS DataBase Reference | 120-66-1(CAS DataBase Reference) | | EPA Substance Registry System | o-Acetotoluidide (120-66-1) |
| 2-METHYLACETANILIDE Usage And Synthesis |
| Chemical Properties | WHITE TO OFF-WHITE CRYSTALLINE POWDER | | Uses | o-Methylacetanilide is a substituted acetanilide that is used as precursor for various pharmaceuticals including their intermediates. | | Uses | Acetanilide is used as an inhibitor of peroxides and?stabilizer for cellulose ester varnishes.?It is used as an intermediate for the synthesis of?rubber accelerators, dyes and dye intermediate and camphor. It is used as a precursor in penicillin synthesis and other pharmaceuticals including painkillers and intermediates. | | Synthesis Reference(s) | Journal of the American Chemical Society, 106, p. 5759, 1984 DOI: 10.1021/ja00331a073Organic Syntheses, Coll. Vol. 5, p. 650, 1973 | | General Description | Colorless crystals. Insoluble in water. | | Air & Water Reactions | Water insoluble. | | Reactivity Profile | 2-METHYLACETANILIDE is an amide. Amides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). | | Health Hazard | ACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products. | | Safety Profile | Moderately toxic by ingestion.Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. | | Purification Methods | Crystallise the toluidide from hot H2O (solubility 1g/210mL), EtOH or aqueous EtOH. UV: max 230 and 280nm (EtOH). [Beilstein 12 H 792, 12 I 376, 12 II 439, 12 III 1853, 12 IV 1755.] |
| 2-METHYLACETANILIDE Preparation Products And Raw materials |
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