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| BMY 7378 DIHYDROCHLORIDE Basic information |
| Product Name: | BMY 7378 DIHYDROCHLORIDE | | Synonyms: | BMY 7378 2hydrochloride;BMY 7378 DIHYDROCHLORIDE;BMY 7378;8-(2-(4-(2-Methoxyphenyl);-8-azaspiro[4.5]decane-7,9-dione dihydrochloride;BMY7378 HCl;1-cyclopentanediacetimide,n-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-d;n-(2-(4-(o-methoxyphenyl)-1-piperazinyl)ethyl)-1,1-cyclopentanediacetimided;BMY 7378 DIHYDROCHLORIDE >98% PARTIAL 5- HT1A SEROTO | | CAS: | 21102-95-4 | | MF: | C22H32ClN3O3 | | MW: | 421.97 | | EINECS: | | Product Categories: | Serotonin receptor;Inhibitors | | Mol File: | 21102-95-4.mol |
| BMY 7378 DIHYDROCHLORIDE Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | solubility | H2O: soluble | | form | solid | | color | white |
| WGK Germany | 3 | | RTECS | GY3996000 |
| BMY 7378 DIHYDROCHLORIDE Usage And Synthesis |
| Uses | BMY 7378 dihydrochloride is a SR-1A agonist and a selective α1D-AR antagonist. | | Biological Activity | 5-HT 1A partial agonist and high affinity α 1D adrenoceptor antagonist (K i values are 2, 800 and 600 nM at cloned rat α 1D , rat α 1A and hamster α 1B receptors respectively). Also available as part of the α 1 -Adrenoceptor Tocriset™ . | | Biochem/physiol Actions | BMY 7378 dihydrochloride is a partial 5-HT1A serotonin receptor agonist and selective α1D-adrenoceptor antagonist. | | references | 1. yocca fd, hyslop dk, smith dw et al. bmy 7378, a buspirone analog with high affinity, selectivity and low intrinsic activity at the 5-ht1a receptor in rat and guinea pig hippocampal membranes. eur j pharmacol. 1987 jun 4;137(2-3):293-4.2. zemlan fp, zieleniewski-murphy a, maureen murphy r et al bmy 7378: partial agonist at spinal cord 5-ht(1a) receptors. neurochem int. 1990;16(4):515-22.3. goetz as, king hk, ward sd et al. bmy 7378 is a selective antagonist of the d subtype of alpha 1-adrenoceptors. eur j pharmacol. 1995 jan 16;272(2-3):r5-6.4. cleary l, murad k, bexis s et al. the alpha (1d)-adrenoceptor antagonist bmy 7378 is also an alpha (2c)-adrenoceptor antagonist. auton autacoid pharmacol. 2005 oct;25(4):135-41.5. sharp t, backus li, hjorth s et al. further investigation of the in vivo pharmacological properties of the putative 5-ht1a antagonist, bmy 7378. eur j pharmacol. 1990 feb 13;176(3):331-40. |
| BMY 7378 DIHYDROCHLORIDE Preparation Products And Raw materials |
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