(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL

CAS No.：14774-37-9

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL Basic information

Product Name:	(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL
Synonyms:	(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL;(TETRAHYDRO-PYRAN-4-YL)-METHANOL;TETRAHYDROPYRAN-4-METHANOL;TERTAHYDROPYRAN-4-METHANOL;4-(Hydroxymethyl)tetrahydro-2H-pyran;4-(Hydroxymethyl)tetrahydropyr;(Tetrahydro-pyran-4-yl)-methanol ,97%;oxan-4-ylMethanol
CAS:	14774-37-9
MF:	C6H12O2
MW:	116.16
EINECS:
Product Categories:	Pyrans, Piperidines &Piperazines;Pyrans, Piperidines & Piperazines;blocks;Alcohols and Derivatives;Heterocycles series;Hydroxymethyl's;Heterocycles
Mol File:	14774-37-9.mol

(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL Chemical Properties

Boiling point	105 °C
density	1.000±0.06 g/cm3(Predicted)
Fp	61°(142°F)
refractive index	1.4600
storage temp.	Sealed in dry,Room Temperature
pka	14.85±0.10(Predicted)
form	clear liquid
color	Colorless to Light yellow to Light orange
Water Solubility	Slightly soluble in water.
CAS DataBase Reference	14774-37-9(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi,Xn
Risk Statements	36/37/38-22-41-37/38
Safety Statements	26-36/37/39-23-39
HazardClass	IRRITANT
HS Code	29329990

MSDS Information

(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL Usage And Synthesis

Chemical Properties	Colorless liquid
Uses	Used as a reagent in the identification and optimization of pteridinone Toll-like receptor 7 agonists, which can be used for the oral treatment of viral hepatitis. 4-(Hydroxymethyl)tetrahydropyran is also a starting material for [1-[(Tetrahydro-2H-pyran-4-yl)methyl]-1H-indol-3-yl](2,2,3,3-tetramethylcyclopropyl)methanone which is a drug that acts as CB2 cannabinoid receptor agonist.

(TETRAHYDRO-2H-PYRAN-4-YL)METHANOL Preparation Products And Raw materials

Raw materials	Ethanol-->Tetrahydrofuran-->Sodium-->Potassium hydroxide-->Acetone-->Lithium Aluminum Hydride-->Diethyl malonate-->Tetrahydro-2H-pyran-4-carboxylic acid-->2,2'-Dichlorodiethyl ether
Preparation Products	Tetrahydropyran-4-carbaldehyde-->1-azabicyclo[2.2.1]heptane-->4-(IODOMETHYL)TETRAHYDRO-2H-PYRAN-->Tetrahydropyranyl-4-acetic acid-->4-BROMOMETHYLTETRAHYDROPYRAN

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