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| 4'-Methylacetophenone Basic information |
| 4'-Methylacetophenone Chemical Properties |
| Hazard Codes | Xn | | Risk Statements | 36/37/38-22-20/21/22 | | Safety Statements | 26-27-37/39-24/25-23-36 | | RIDADR | UN 1325 4.1/PG 2 | | WGK Germany | 3 | | RTECS | AM9463000 | | TSCA | Yes | | HS Code | 29143900 | | Toxicity | LD50 orally in Rabbit: 1400 mg/kg LD50 dermal Rabbit > 2000 mg/kg |
| 4'-Methylacetophenone Usage And Synthesis |
| Description | 4'-Methylacetophenone has a fruity, floral odor resembling acetophenone and a sweet, strawberry-like flavor. May be prepared
by slow addition of acetyl chloride to a mixture of toluene and
AlCl in an ice bath and under vacuum, maintaining the temperature
at +5°C and then letting it increase to +20°C. | | Chemical Properties | 4?-Methylacetophenone has a fruity, floral odor resembling acetophenone and a sweet, strawberry-like flavor. | | Chemical Properties | clear colourless to pale yellowish liquid | | Chemical Properties | 4'-Methylacetophenone has
been identified in Brazilian rosewood oil and in pepper. It occurs as colorless crystals with a floral, sweet odor that is milder than that of acetophenone.
4-Methylacetophenone is prepared from toluene and acetic anhydride or acetyl
chloride by a Friedel–Crafts reaction. It is used for blossom notes in mimosaand
hawthorn-type perfumes, especially soap perfumes. | | Occurrence | Reported found in the essential oil distilled from the wood of Myrocarpus fastigiatus, Myrocarpus frondo sus, Bois de Rose. Also reported found in sour cherry, orange and grapefruit peel oil, black currants, guava, peach, blackberry,
celery, potato, tomato, mentha oils, pepper, parsley, smoked fish, cognac, parmesan cheese, cocoa, tea, soybean, cloudberry,
mango, cauliflower, broccoli, rice bran, buckwheat, dried bonito, cherimoya, calabash nutmeg and mastic gum leaf oil, cooked
cabbage, mandarin juice. | | Uses | 4'-Methylacetophenone is a methylated acteophenone used in cosmetics and perfumery. The presence of 4'-Methylacetophenone has been shown to accelerate the photopolymerization of Methyl methacrylate. | | Uses | 4'-Methylacetophenone is used as a flavoring agent. It reacts with morpholine to get 4-(p-tolyl-thioacetyl)-morpholine in the presence of sulfur as a reagent. Further, it is used as an intermediate in the manufacture of active pharmaceutical ingredients, perfumes and cosmetics. | | Preparation | By slow addition of acetyl chloride to a mixture of toluene and AlCl in an ice bath and under vacuum, maintaining the
temperature at +5°C and then letting it increase to +20°C. | | Taste threshold values | Taste characteristics at 20 ppm: sweet, creamy, fruity, cherry and heliotropine-like. | | Synthesis Reference(s) | Journal of the American Chemical Society, 110, p. 2560, 1988 DOI: 10.1021/ja00216a032Tetrahedron Letters, 27, p. 2965, 1986 DOI: 10.1016/S0040-4039(00)84691-2 | | General Description | 4′-Methylacetophenone occurs naturally in mango, tomato and orange. | | Safety Profile | Moderately toxic by
ingestion. A human skin irritant. A
flammable liquid. When heated to
decomposition it emits acrid smoke and
irritating fumes. See also KETONES. | | Purification Methods | Impurities, including the o-and m-isomers, are removed by forming the semicarbazone (m 212-213.5o) which, after repeated crystallisation, is hydrolysed to the ketone. [Brown & Marino J Am Chem Soc 84 1236 1962.] It can also be purified by distillation under reduced pressure, followed by low temperature crystallisation from isopentane. [Beilstein 7 IV 701.] |
| 4'-Methylacetophenone Preparation Products And Raw materials |
| Raw materials | Aluminum chloride-->Acetyl chloride-->Benzyl chloride-->Semicarbazide | | Preparation Products | 4-(1,2,3-THIADIAZOL-4-YL)BENZOYL CHLORIDE-->4-(1,2,3-THIADIAZOL-4-YL)BENZYLAMINE HYDROCHLORIDE-->4-(1,2,3-THIADIAZOL-4-YL)BENZALDEHYDE-->4-[4-(BROMOMETHYL)PHENYL]-1,2,3-THIADIAZOLE-->5-P-TOLYL-3H-THIENO[2,3-D]PYRIMIDIN-4-ONE-->ETHYL 2-AMINO-4-(4-METHYLPHENYL)-3-THIOPHENECARBOXYLATE-->4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE-->4-Acetylbenzoic acid-->4-Ethynyltoluene-->CYAZOFAMID-->Naphthalene, 1,2,3,4-tetrahydro-1,6-dimethyl-4-(1-methylethyl)-, (1R,4R)-rel--->ar-turmerone-->2-Bromo-4'-methylacetophenone-->Methyl 4-methylbenzoate-->3,5-DIBROMO-4-METHYLBENZOIC ACID-->2-AMINO-4-(P-TOLYL)THIAZOLE-->1-(4-(Bromomethyl)phenyl)ethanone |
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