(R)-(-)-3-Pyrrolidinol hydrochloride

CAS No.：104706-47-0

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

View the full Disclaimer

Other grades of this product :

(R)-(-)-3-Pyrrolidinol hydrochloride Basic information

Product Name:	(R)-(-)-3-Pyrrolidinol hydrochloride
Synonyms:	(R)-(-)-3-PYRROLIDINOL HCL;(R)-3-Hydroxypyrrolidine hydrochloride, (R)-3-Pyrrolidinol hydrochloride;(3R)-Pyrrolidin-3-ol hydrochloride;(R)-()-3-Pyrrolidinol hydrochloride ,97%;(R)-3-Hydroxypyrroli;(3R)-3-Hydroxypyrrolidine hydrochloride;(R)-3-Pyrrolindinol hydrochloride;(R)-3-HYDROXYPYRROLIDINE HYDROCHLORIDE
CAS:	104706-47-0
MF:	C4H10ClNO
MW:	123.58
EINECS:	600-598-9
Product Categories:	Chiral Building Blocks;Simple Alcohols (Chiral);chiral;Benzenes;Synthetic Organic Chemistry;Chiral chemicals;Alcohols and Derivatives;APIs Intermediate;pharmacetical;Pyrrole&Pyrrolidine&Pyrroline;11
Mol File:	104706-47-0.mol

(R)-(-)-3-Pyrrolidinol hydrochloride Chemical Properties

Melting point	104-107 °C(lit.)
alpha	-7.6°(20/D, c=3,5, CH3OH)
refractive index	-7.8 ° (C=3.5, MeOH)
storage temp.	Inert atmosphere,Room Temperature
solubility	Soluble in DMSO.
form	Solid
color	Pale Brown
optical activity	[α]20/D 7.6°, c = 3.5 in methanol
BRN	4450078
InChIKey	QPMSJEFZULFYTB-PGMHMLKASA-N
CAS DataBase Reference	104706-47-0(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38-41-38-37
Safety Statements	26-36-38
WGK Germany	3
F	3-10
HS Code	29339900

MSDS Information

Provider	Language
SigmaAldrich	English

(R)-(-)-3-Pyrrolidinol hydrochloride Usage And Synthesis

Chemical Properties	Llight brown crystalline
Uses	(R)-(-)-3-Pyrrolidinol hydrochloride is a chiral hydroxy derivative of pyrrlodine used in the preparation of chiral niologically active compounds such as muscarinic receptor antagonists and antimicrobial agents.
Uses	(R)-3-Hydroxypyrrolidine hydrochloride is used as a darifenacin Intermediate.
Uses	(R)-3-Pyrrolidinol hydrochloride can be used as a building block to synthesize: Biaryl carboxamide functional groups containing bis-aminopyrrolidine ureas as potential antagonists of the melanin-concentrating hormone receptor-1. Pyrrolidinol based ionic liquids. Optically active 2-tritylpyrrolidine based organocatalysts.
Purification Methods	The (±)-isomer is purified by repeated distillation ( b 102-104o/12mm, 108-110o/18mm), and the (±)-picrate crystallises from EtOH with m 140-141o. The R(+)-enantiomer has b 70o/0.6mm and [] D +5.6o (c 3.63, MeOH). Its hydrochloride has a negative rotation and its dimethiodide has m 230o and [] 24 -8.02o. [Suyama & Kanno Yakugaku Zasshi (J Pharm Soc Japan) 85 531 1965, Uno et al. J Heterocycl Chem 24 1025 1987, Flanagan & Joullie Heterocycles 26 2247 1987, Beilstein 21 III/IV 44.]

(R)-(-)-3-Pyrrolidinol hydrochloride Preparation Products And Raw materials

Raw materials

Ethanol-->Sodium hydroxide-->Hydrochloric acid-->Ethyl acetate-->Methanol-->Tetrahydrofuran-->Dichloromethane-->Acetic acid-->PETROLEUM ETHER-->Lithium Aluminum Hydride-->Sodium borohydride-->Acetyl chloride-->Calcium chloride-->Benzylamine-->Cyclohexanol-->HEAVY DISTILLATE-->L-Hydroxyproline-->2-Cyclohexen-1-one-->D(+)-Malic acid

Welcome！

Please leave a message for us or use the following ways to contact us, we will reply to you as soon as possible, and provide you with the most sincere service, thank you.

NO. 18 ,Wujiang Road, Wulidian Street, Jiangbei District, Chongqing
+86-23-6139-8061 +86-13650506873
danny@chemdad.com sales@chemdad.com
www.chemdad.com
WhatsApp +86-13650506873