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| 2-Methylimidazole Basic information |
| 2-Methylimidazole Chemical Properties |
| Melting point | 142-143 °C (lit.) | | Boiling point | 267-268 °C (lit.) | | density | 1.0500 (rough estimate) | | vapor pressure | <1 mm Hg ( 0 °C) | | refractive index | 1.4970 (estimate) | | Fp | 155 °C | | storage temp. | 2-8°C | | solubility | 780g/l | | pka | 14.44±0.10(Predicted) | | form | Crystalline Powder | | color | White to light yellow | | PH | 10.5-11.5 (100g/l, H2O, 20℃) | | PH Range | 10.5 | | Water Solubility | Soluble in water and ethanol. | | BRN | 1368 | | InChIKey | LXBGSDVWAMZHDD-UHFFFAOYSA-N | | LogP | 0.22 at 25℃ | | CAS DataBase Reference | 693-98-1(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-Imidazole, 2-methyl-(693-98-1) | | IARC | 2B (Vol. 101) 2013 | | EPA Substance Registry System | 2-Methylimidazole (693-98-1) |
| Hazard Codes | C | | Risk Statements | 22-34 | | Safety Statements | 26-36/37/39-45-25 | | RIDADR | UN 3259 8/PG 2 | | WGK Germany | 2 | | RTECS | NI7175000 | | Autoignition Temperature | >600 °C DIN 51794 | | Hazard Note | Harmful/Corrosive | | TSCA | Yes | | HazardClass | 8 | | PackingGroup | III | | HS Code | 29332990 | | Hazardous Substances Data | 693-98-1(Hazardous Substances Data) | | Toxicity | LD50 orally in Rabbit: 1500 mg/kg |
| 2-Methylimidazole Usage And Synthesis |
| Chemical Properties | 2-Methylimidazole is a white to light yellow crystalline powder with an amine-like odor. It is highly soluble in polar organic solvents. Insoluble in ether and cold benzene, easily soluble in water, alcohols and ketones. Irritating to skin and mucous membranes. Mice orally LD50 1400mg/kg. | | Uses | 2-Methylimidazole is a monomethylated imidazole that can be used as a building block in the preparation of a wide range of biologically active compounds. 2-Methylimidazole as well as other imidazoles
can be use as catalyst for refolding of enhanced coloured fluorescent protein. 2-Methylimidazole has been identified as a byproduct of fermentation and is detected in foods and mainstream and side-str
eam tobacco smoke. | | Uses | 2-Methylimidazole is used as a raw material for the preparation of nitroimidazole antibiotics, which is useful in combat anaerobic bacterial and parasitic infections. It acts as a ligand in coordination chemistry. It is also employed as a hardener or accelerator for epoxy resin and auxiliary agent for textile dyes. Further, it acts as a catalyst for refolding of enhanced colored fluorescent protein. It is also useful as a building block in the synthesis of biologically active compounds. In addition to this, it is used as an active pharmaceutical ingredient intermediate such as metronidazole and dimetridazole. | | Preparation | 2-Methylimidazole is prepared by condensation of glyoxal, ammonia and acetaldehyde, a Radziszewski reaction. It is widely used as a polymeriza tion cross-linking accelerator and a hardener for epoxy resin systems for semiconductor potting compounds and soldering masks. It is obtained by eliminating dehydrogenation of 2-methylimidazoline. 2-methylimidazoline heated to melt (melting point 107 ℃), carefully add active nickel, raise the temperature to 200-210 ℃ reaction 2h. cool down to below 150 ℃, add water to dissolve, while hot pressure filtration, separation of active nickel, the filter Chemicalbook liquid concentrated to a temperature of 140 ℃ or more, put the material cooling that 2-methylimidazole. Use the method to produce purity of ≥ 98% of the product, 1t product consumption of ethylenediamine (95%) 1095kg, acetonitrile 975kg. better method is to use glyoxal and aldehyde as raw materials. | | General Description | It is a white or colorless solid that is highly soluble in polar organic solvents and water. It is a precursor to a range of drugs and is a ligand in coordination chemistry. | | Hazard | Possible carcinogen. | | Flammability and Explosibility | Notclassified | | Purification Methods | Recrystallise 2-methylimidazole from *benzene or pet ether. The picrate has m 215o (from H2O). [Beilstein 23 III/IV 594, 23/5 V 35.] |
| 2-Methylimidazole Preparation Products And Raw materials |
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