5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE

CAS No.：42518-98-9

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Basic information

Product Name:	5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE
Synonyms:	5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE;5-CHOROTHIOPHENE-2-ARBONYL CHLORIDE;5-Chlorothiophene-2-carbonyl chloride ,97%;2-Thiophenecarbonyl chloride, 5-chloro- (9CI);5-Chorothiophene-2-carbonyl chloride;2-thiophenecarbonyl chloride, 5-chloro-;5-Chloro-2-thiophenecarbonyl chloride;2-Chloro-5-(chlorocarbonyl)thiophene, 2-Chloro-5-(chloroformyl)thiophene
CAS:	42518-98-9
MF:	C5H2Cl2OS
MW:	181.04
EINECS:	800-982-8
Product Categories:	ACIDHALIDE
Mol File:	42518-98-9.mol

5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Chemical Properties

Melting point	4℃
Boiling point	122-127℃/16Torr
density	1.50
refractive index	1.6040 to 1.6080
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Oil
color	Colourless to Pale Yellow
Water Solubility	Slightly soluble in water.
Sensitive	Moisture Sensitive
Stability:	Hygroscopic
CAS DataBase Reference	42518-98-9(CAS DataBase Reference)

Safety Information

Risk Statements	36-43
Safety Statements	26-36
RIDADR	3265
HazardClass	IRRITANT
HazardClass	8
PackingGroup	Ⅲ
HS Code	29339900

MSDS Information

5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Usage And Synthesis

Chemical Properties	Colorless to light yellow liquid
Uses	5-Chlorothiophene-2-carbonyl chloride used as a intermediate for rivaroxaban.

5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Preparation Products And Raw materials

Raw materials	Hydrochloric acid-->Diethyl ether-->Sodium-->Thionyl chloride-->2,5-Dichlorothiophene-->CHLORODIFLUOROACETYL CHLORIDE-->TRIBROMOACETYL CHLORIDE-->5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID-->2-ACETYL-5-CHLOROTHIOPHENE-->2-Chlorothiophene-->Sulfolane-->Trichloroacetyl chloride
Preparation Products	(S)-2-(2-(5-chloro-N-(4-(5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)thiophene-2-carboxamido)ethoxy)acetic acid

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