6-Cyano-2-naphthol

CAS No.：52927-22-7

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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6-Cyano-2-naphthol Basic information

Product Name:	6-Cyano-2-naphthol
Synonyms:	6-CYANO-2-NAPHTHOL;6-HYDROXY-NAPHTHALENE-2-CARBONITRILE;6-HYDROXY-2-NAPHTHALENECARBONITRILE;6-HYDROXY-2-NAPHTHONITRILE;6-CYANO-2-NAPHTHOL 99%;6-CYANO-2-NAPHTHALENOL;CYANO(6-)-2-NAPTHOL;6-Cyano-2-naphthol (Nafamostat mesylate)
CAS:	52927-22-7
MF:	C11H7NO
MW:	169.18
EINECS:	628-663-7
Product Categories:	alcohol\|cyanide;Intermediates;Aromatics Compounds;Building Blocks for Liquid Crystals;Intermediates & Fine Chemicals;Pharmaceuticals;Chalcones, etc. (Building Blocks for Liquid Crystals);Functional Materials;Aromatics;C10 to C27;Cyanides/Nitriles;Nitrogen Compounds
Mol File:	52927-22-7.mol

6-Cyano-2-naphthol Chemical Properties

Melting point	165.5-170.5 °C (lit.)
Boiling point	383.1±15.0 °C(Predicted)
density	1.28±0.1 g/cm3(Predicted)
storage temp.	Sealed in dry,Room Temperature
solubility	DMSO (Slightly), Ethanol, Ethyl Acetate (Slightly), Methanol (Slightly)
form	Solid
pka	8.57±0.40(Predicted)
color	Pale Brown to Brown
CAS DataBase Reference	52927-22-7(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HS Code	29269090

MSDS Information

Provider	Language
SigmaAldrich	English

6-Cyano-2-naphthol Usage And Synthesis

Chemical Properties	Brown Crystalline Solid
Uses	Intermediate of Nafamostat mesilate (N210000).
Uses	Reactant for: Palladium-catalyzed reduction Nickel-catalyzed cross-coupling reactions Palladium-catalyzed Heck reactions
General Description	6-Cyano-2-naphthol (6CN2) is an aromatic alcohol that can be synthesized from 6-bromo-2-naphthol. It is a superphotoacid with the ground state pK_a^* value of 8.4 and excited state pKavalue of 0.2, respectively. 6CN2 protonates PANI-ES (polyaniline emeraldine salt) to form PANI-EB (emeraldine base), which shows enhanced conductivity. The proton-transfer kinetics and photophysical behavior of 6CN2 have been investigated.

6-Cyano-2-naphthol Preparation Products And Raw materials

Preparation Products

6-AMIDINO-2-NAPHTHOL, HYDROCHLORIDE-->NAFAMOSTAT MESYLATE

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