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| 3,4-Dimethoxyacetophenone Basic information | | Synthesis |
| Product Name: | 3,4-Dimethoxyacetophenone | | Synonyms: | Dimethoxyacetophenone;3,4-Dimethoxyacetoph;3,4-DIMETHOXYACETOPHENONE FOR SYNTHESIS;3,4-Dimethoxyacetophenone≥ 99% (GC);3',4'-DIMETHOXYACETOPHENONE;3,4-DIMETHOXYACETOPHENONE;3,4-dimethoxyacetophenone (acetoveratrone);3',4'-Dimethoxyacetophenone 1-(3,4-Dimethoxyphenyl)ethan-1-one 3,4-Dimethoxyacetophenone | | CAS: | 1131-62-0 | | MF: | C10H12O3 | | MW: | 180.2 | | EINECS: | 214-468-0 | | Product Categories: | Alphabetical Listings;C-D;Flavors and Fragrances;C10;Carbonyl Compounds;Ketones;Benzene derivatives;Aromatic Acetophenones & Derivatives (substituted);1131-62-0 | | Mol File: | 1131-62-0.mol |
| 3,4-Dimethoxyacetophenone Chemical Properties |
| Hazard Codes | Xi | | Safety Statements | 24/25 | | WGK Germany | 3 | | TSCA | Yes | | HS Code | 29145000 |
| 3,4-Dimethoxyacetophenone Usage And Synthesis |
| Synthesis |
To a stirred mixture of 3´,4´-dihydroxyacetophenone (100 mg, 0.66 mmol) and anhydrous K2CO3 (5 g, 36 mmol) in dry acetone (10 mL) was added MeI (1 mL, 16 mmol). The mixture was heated at reflflux for 45 min, cooled to room temperature, fifiltered, and evaporated under reduced pressure. The residue was dissolved in CH2Cl2, washed with 2 portions of water, dried over anhydrous Na2SO4, and evaporated under reduced pressure. The product was purifified by flflash chromatography (silica, hexane/EtOAc 4:1, v/v). Removal of the solvent gave a 93% yield of the product, 3´,4´-dimethoxyacetophenone (110 mg, 0.61 mmol). Reference: Khatib, S.; Nerya, O.; Musa, R.; Shmuel, M.; Tamir, S.; Vaya, J. Bioorg. Med. Chem. 2005, 13, 433−441.
| | Chemical Properties | yellow to beige crystalline powder | | Uses | 3',4'-Dimethoxyacetophenone is used as Catalytic agent; Petrochemical additive. It is also used in agrochemical, pharmaceutical and dyestuff field. | | Definition | ChEBI: A member of the class of acetophenones that is acetophenone substituted by methoxy groups at positions 3' and 4' respectively. | | Preparation | Obtained by reaction of dimethyl sulfate with acetoguaiacone in the presence of sodium hydroxide in ethanol, first at 50°, then at reflux for 1 h (78%). | | Synthesis Reference(s) | Tetrahedron Letters, 36, p. 409, 1995 DOI: 10.1016/0040-4039(94)02221-V |
| 3,4-Dimethoxyacetophenone Preparation Products And Raw materials |
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