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| Maleimide Basic information |
| Maleimide Chemical Properties |
| Melting point | 91-93 °C (lit.) | | Boiling point | 97-103°C 5mm | | density | 1,2493 g/cm3 | | refractive index | 1.4543 (estimate) | | Fp | 97-103°C/5mm | | storage temp. | Inert atmosphere,Room Temperature | | solubility | soluble in Methanol | | pka | 8.52±0.20(Predicted) | | form | Fine Crystalline Powder | | color | White to slightly yellow | | Water Solubility | SOLUBLE | | λmax | 280nm(EtOH)(lit.) | | BRN | 106910 | | InChIKey | PEEHTFAAVSWFBL-UHFFFAOYSA-N | | CAS DataBase Reference | 541-59-3(CAS DataBase Reference) | | NIST Chemistry Reference | 1H-pyrrole-2,5-dione(541-59-3) | | EPA Substance Registry System | 1H-Pyrrole-2,5-dione (541-59-3) |
| Maleimide Usage And Synthesis |
| Chemical Properties | slight yellow crystalline powder | | Uses | Rhodium-catalyzed conjugate arylation with arylboronic acids.1 | | Uses | Reacts quantitatively with sulfhydryl groups.Maleimide is used to immobilize the bovine serum albumin-boronic acid conjugates in association with silica beads. Its nanoparticle surface favors the conjugation with cell penetration peptides. It is involved in Rhodium-catalyzed conjugate arylation with arylboronic acids. It is actively involved in Michael additions and Diels-Alder reactions by the addition across the double bond. It acts as crosslinking reagents in polymer chemistry. | | Definition | ChEBI: A cyclic dicarboximide in which the two carboacyl groups on nitrogen together with the nitogen itself form a 1H-pyrrole-2,5-dione structure. | | General Description | Maleimide (2,5-Pyrroledione) is a new nanoparticle surface functional group which favors easy conjugation with cell penetration peptides. The conjugation is enabled via click chemistry to preserve its biofunctions. | | Hazard | A poison. | | Safety Profile | Poison by
intraperitoneal and intravenous routes. An
experimental teratogen. Experimental
reproductive effects. When heated to
decomposition it emits toxic fumes of NOx. | | Purification Methods | Purify it by sublimation in a vacuum. The UV has max at 216 and 280nm in EtOH. [de Wolf & van de Straete Bull Soc Chim Belg 44 288 1935, UV: Rondestvedt et al. J Am Chem Soc 78 6115 1956, IR: Chiorboli & Mirone Ann Chim (Rome) 42 681 1952, Beilstein 21/10 V 3.] |
| Maleimide Preparation Products And Raw materials |
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