2-Bromo-6-nitrophenol

CAS No.：13073-25-1

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This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
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2-Bromo-6-nitrophenol Basic information

Product Name:	2-Bromo-6-nitrophenol
Synonyms:	TIMTEC-BB SBB008567;2-Bromo-6-nitropheno;3-Bromo-2-hydroxynitrobenzene;2-BROMO-6-NITROPHENOL;6-NITRO-2-BROMOPHENOL;Phenol, 2-broMo-6-nitro-;6-BroMo-2-nitrophenol;2-BroMo-6-nitrophenol, 97+%
CAS:	13073-25-1
MF:	C6H4BrNO3
MW:	218
EINECS:	629-309-4
Product Categories:	Fluorobenzene;Aromatic Phenols;Phenol&Thiophenol&Mercaptan;Organic Building Blocks;Oxygen Compounds;Phenols
Mol File:	13073-25-1.mol

2-Bromo-6-nitrophenol Chemical Properties

Melting point	66-70 °C (lit.)
Boiling point	227.2±20.0 °C(Predicted)
density	1.881±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,Room Temperature
solubility	Chloroform; Methanol
form	Solid
pka	5.36±0.24(Predicted)
color	Yellow
CAS DataBase Reference	13073-25-1(CAS DataBase Reference)
EPA Substance Registry System	2-Bromo-6-nitrophenol (13073-25-1)

Safety Information

Hazard Codes	Xn,Xi
Risk Statements	22-36/37/38
Safety Statements	36/37-26
WGK Germany	3
Hazard Note	Harmful
HazardClass	IRRITANT
HS Code	29089990

MSDS Information

Provider	Language
SigmaAldrich	English

2-Bromo-6-nitrophenol Usage And Synthesis

Chemical Properties	White solid
Uses	2-Bromo-6-nitrophenol is an intermediate used in the synthesis of N-Hydroxy Eltrombopag (H825795), which is a derivative compound of Eltrombopag (508000), an agonist of the Thrombopoietin (Tpo) receptor, used as treatment for thrombocytopenia.

2-Bromo-6-nitrophenol Preparation Products And Raw materials

Raw materials	1-Bromo-2-nitrobenzene-->3-Bromo-2-nitrophenol-->3-Bromo-4-nitrophenol-->1-Bromo-2-methoxy-3-nitro-benzene-->2-Bromo-4-nitrophenol-->Piperidine-->2-Nitrophenol
Preparation Products	3''-AMINO-2''-HYDROXY-BIPHENYL-3-CARBOXYLIC ACID-->2,4-DIBROMO-6-NITROPHENOL-->2-Bromo-3-nitrophenol-->4-Bromo-2-nitrophenol

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