Other grades of this product :
| PICROTIN Basic information |
| Product Name: | PICROTIN | | Synonyms: | PICROTIN;(1aR,8aS,9S)-1aβ,2,2a,6,6aα,8b-Hexahydro-2aα-hydroxy-9-(1-hydroxy-1-methylethyl)-8bα-methyl-3α,6α-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione;(1aR,2aR,3S,6R,6aS,8aS,8bR,9S)-Hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-3,6-methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione;Picrotin CRS;3,6-Methano-8H-1,5,7-trioxacyclopenta[ij]cycloprop[a]azulene-4,8(3H)-dione, hexahydro-2a-hydroxy-9-(1-hydroxy-1-methylethyl)-8b-methyl-, (1aR,2aR,3S,6R,6aS,8aS,8bR,9S)- | | CAS: | 21416-53-5 | | MF: | C15H18O7 | | MW: | 310.3 | | EINECS: | | Product Categories: | Plant Oils, Toxins, Phenolic Acids & Derivatives | | Mol File: | 21416-53-5.mol |
| PICROTIN Chemical Properties |
| Melting point | 256-258°C | | alpha | D -64.7° (c = 2.31 in abs alc) | | Boiling point | 595.8±50.0 °C(Predicted) | | density | 1.59 | | storage temp. | 2-8°C | | pka | 13.28±0.60(Predicted) | | form | neat | | EPA Substance Registry System | Picrotin (21416-53-5) |
| WGK Germany | 3 | | RTECS | TJ8800000 | | Toxicity | LD50 i.p. in mice: 135 mg/kg (Jarboe) |
| PICROTIN Usage And Synthesis |
| Description | Picrotin is a natural picrotoxane that antagonizes glycine receptors (GlyRs; IC50s = 57 and 117 μM for α1 and α2 homodimeric GlyRs, respectively). It also inhibits α3 homodimeric GlyRs. Picrotin is inactive in inhibiting γ-aminobutyric acid (GABA) type A and type C receptors. Picrotin occurs in the natural plant-derived poison picrotoxin , equimolar with picrotoxinin. | | Uses | GABAa receptor antagonist |
| PICROTIN Preparation Products And Raw materials |
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