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| 4-Bromophenol Basic information |
| 4-Bromophenol Chemical Properties |
| Melting point | 61-64 °C (lit.) | | Boiling point | 235-236 °C (lit.) | | density | 1.84 | | refractive index | 1.5085 (estimate) | | Fp | 235-238°C | | storage temp. | room temp | | solubility | 14g/l | | form | Crystalline Solid | | pka | 9.37(at 25℃) | | color | Pinkish-brown | | Water Solubility | It is insoluble in water. It is soluble in 5%ethanol. | | λmax | 282nm(EtOH)(lit.) | | Merck | 14,1428 | | BRN | 1680024 | | CAS DataBase Reference | 106-41-2(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Bromophenol(106-41-2) | | EPA Substance Registry System | Phenol, 4-bromo- (106-41-2) |
| 4-Bromophenol Usage And Synthesis |
| Chemical Properties | 4-Bromophenol is a pinkish-brown crystalline solid. four-sided biconical crystal precipitated from ether or chloroform. The melting point is 66.4 ℃, and a small amount of water can reduce the melting point a lot. Soluble in water, chloroform, easily soluble in ethanol, ether and glacial acetic acid, soluble in 7 parts of water. | | Uses | 4-Bromophenol is used as an intermediate in medicine grade. It is also used as a phenol that is used in Stille reactions. It is used in the intermediate of organic synthesis, flame retardant and pharmaceutical industry. | | Application | 4-Bromophenol is a phenolic derivative that It can used as a reagent in Stille reactions or Intermediates of Liquid Crystals. | | Preparation | 4-Bromophenol is synthesized by bromination of phenol. The bromine and carbon disulfide solution was added to the phenolic carbon disulfide solution, and the addition was started below 5°C, and the addition was completed under stirring for 2 hours. Phenol and bromine are approximately equimolar ingredients. Distill the reactant to remove carbon disulfide, and then conduct fractional distillation under reduced pressure to collect fractions at 145-150°C (3.32-3.99kPa) to obtain the product. Yield 80-84%. | | Synthesis Reference(s) | Tetrahedron, 45, p. 7869, 1989 DOI: 10.1016/S0040-4020(01)85800-2The Journal of Organic Chemistry, 23, p. 280, 1958 DOI: 10.1021/jo01096a033 | | Purification Methods | Crystallise the phenol from CHCl3, CCl4, pet ether (b 40-60o), or water and dry it at 70o under vacuum for 2hours. [Beilstein 6 IV 1043.] |
| 4-Bromophenol Preparation Products And Raw materials |
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