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| [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Basic information |
| Product Name: | [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone | | Synonyms: | [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone;KW 2449;(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanone;KW2449(E)-(4-(2-(1H-indazol-3-yl)vinyl)phenyl)(piperazin-1-yl)methanonehydrochloride;KW-2449;KW 2449; KW2449;[4-[(E)-2-(1H-indazol-3-yl)ethenyl]phenyl]-piperazin-1-ylmethanone;KW-2449 100MG;{4-[(E)-2-(1H-Indazol-3-yl)vinyl]phenyl}(1-piperazinyl)methanone | | CAS: | 1000669-72-6 | | MF: | C20H20N4O | | MW: | 332.4 | | EINECS: | | Product Categories: | Inhibitors;Inhibitor | | Mol File: | 1000669-72-6.mol |
| [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Chemical Properties |
| Boiling point | 604.1±55.0 °C(Predicted) | | density | 1.28 | | storage temp. | -20°C | | solubility | Soluble in DMSO (>25 mg/ml) | | pka | 13.76±0.40(Predicted) | | form | solid | | color | Pale yellow | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. |
| [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Usage And Synthesis |
| Description | KW-2449 is a potent multikinase inhibitor (IC50’s: FLT3 = 7 nM, FGFR1 = 36 nM, Abl = 14 nM, Abl-T315 = 4 nM) with anti-leukemic effects.1,2,3 | | References | Shiotsu et al. (2007) KW-2449, a Novel Multi-Kinase Inhibitor Against FLT3, Abl, FGFR1, and Aurora, Suppresses the Growth of AML Both In Vitro and In Vivo; Blood; 110 1832
Shiotsu et al. (2009) KW-2449, a Novel Multi-Kinase Inhibitor, suppresses the growth of leukemia cells with FLTY3 mutations or T315l-mutated BCR/ABL translocation; Blood; 114 1607
Pratz et al. (2009) A pharmacodynamic study of the FLT3 inhibitor KW-2449 yields insight into the basis for clinical response; Blood; 113 3938 |
| [4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone Preparation Products And Raw materials |
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![[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone](/img/1000669-72-6.jpg "[4-[2-(1H-Indazol-3-yl)ethenyl]phenyl]-1-piperazinylmethanone")
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