3-Ethyl-4-methyl-3-pyrrolin-2-one
3-Ethyl-4-methyl-3-pyrrolin-2-one
  • CAS No.:766-36-9
Other grades of this product :
3-Ethyl-4-methyl-3-pyrrolin-2-one Basic information
Product Name:3-Ethyl-4-methyl-3-pyrrolin-2-one
Synonyms:3-Ethyl-4-methyl-3-pyrrolin-2-one Manufacturer;3-Ethyl-4-methyl-3-pyrrolin-2-one98%;3-ETHYL-4-METHYL-2-OXO-3-PYROLINE;3-Ethyl-1,5-dihydro-4-methyl-2;3-ETHYL-4-METHYL-3-PYRROLIN-2-ONE/INTERMEDIATE OF GLIMEPIRIDE;3-ETHYL-4-METHYL-PYRROL-2-ONE 98+%;3-Ethyl-4-methyl-3-pyrrolin-2-one 98%;3-ETHYL-1,5-DIHYDRO-4-METHYL-2H-PYRROL-2-ONE
CAS:766-36-9
MF:C7H11NO
MW:125.17
EINECS:616-364-4
Product Categories:Building Blocks;Heterocyclic Building Blocks;pharmacetical;(intermediate of glimepiride);Pyrrolines
Mol File:766-36-9.mol
3-Ethyl-4-methyl-3-pyrrolin-2-one Chemical Properties
Melting point 100-104 °C (lit.)
Boiling point 279.0±23.0 °C(Predicted)
density 0.977±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
form powder to crystal
pka14.44±0.60(Predicted)
color White to Almost white
Water Solubility Slightly soluble in water.
CAS DataBase Reference766-36-9(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Safety Statements 22-24/25
WGK Germany 3
Hazard Note Irritant
HS Code 29337900
MSDS Information
ProviderLanguage
SigmaAldrich English
3-Ethyl-4-methyl-3-pyrrolin-2-one Usage And Synthesis
Uses3-Ethyl-4-methyl-3-pyrrolin-2-one is used as an intermediate for the manufacture of medicines. It is used for the preparation of Glimepiride (G410150), and its intermediates and as antidiabetic agents.
General Description3-Ethyl-4-methyl-3-pyrrolin-2-one, a five-membered α,β-unsaturated lactam derivative, has various applications in medicinal chemistry. It can be synthesized by employing following as starting materials:
  • allylamine, via palladium(II)-assisted cyclization
  • 4-methoxybenzylamine, via a ring-closing-metathesis strategy
  • 3-ethyl-1-(4-methoxybenzyl)-4-methyl-1,5-dihydro-2H-pyrrol-2- one
3-Ethyl-4-methyl-3-pyrrolin-2-one Preparation Products And Raw materials
Raw materialsEthyl acetoacetate
Preparation Products4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide

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