Ethylenebis(oxyethylenenitrilo)tetraacetic acid

CAS No.：67-42-5

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Ethylenebis(oxyethylenenitrilo)tetraacetic acid Basic information

Description

Product Name:	Ethylenebis(oxyethylenenitrilo)tetraacetic acid
Synonyms:	3,6-DIOXAOCTAMETHYLENEDINITRILOTETRAACETIC ACID;1,2-bis(2-dicarboxymethylaminoethoxy)ethane;12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)-9-dioxa-3;6,9-Dioxa-3,12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)-;9-Dioxa-3,12-diazatetradecanedioicacid,3,12-bis(carboxymethyl)-6;ebonta;ethylenedioxybis(ethyleneamino)tetraaceticacid;ETHYLENE GLYCOL BIS-(BETA-AMINOETHYLETHER)-N,N,N',N'-TETRAACETIC
CAS:	67-42-5
MF:	C14H24N2O10
MW:	380.35
EINECS:	200-651-2
Product Categories:	Analytical Chemistry;Chelating Reagents;Complexones;EDTA Analogs
Mol File:	67-42-5.mol

Ethylenebis(oxyethylenenitrilo)tetraacetic acid Chemical Properties

Melting point	241 °C (dec.)(lit.)
Boiling point	507.99°C (rough estimate)
density	1.2838 (rough estimate)
refractive index	1.4590 (estimate)
storage temp.	room temp
solubility	0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
pka	1.47±0.10(Predicted)
form	Crystalline Powder
color	White
Water Solubility	slightly soluble
Merck	14,3529
BRN	1717370
CAS DataBase Reference	67-42-5(CAS DataBase Reference)
EPA Substance Registry System	Ethylenebis(oxyethylenenitrilo)tetraacetic acid (67-42-5)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	24/25-36-26
WGK Germany	2
RTECS	AH3760000
TSCA	Yes
HS Code	29225000
Toxicity	LD50 orally in Rabbit: 3587 mg/kg

MSDS Information

Provider	Language
Ethylenebis(oxyethylenenitrilo)tetraacetic acid	English
ACROS	English
SigmaAldrich	English
ALFA	English

Ethylenebis(oxyethylenenitrilo)tetraacetic acid Usage And Synthesis

Description	Ethylenebis(oxyethylenenitrilo)tetraacetic acid is also named as Egtazic acid. It works as a chelating agent for the determination of calcium in the presence of magnesium.
Chemical Properties	White to slightly off-white powder
Uses	Pharmaceutic aid. EGTA.
Uses	Ethylene glycol-O,O'-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid is a chelating agent used for making complexes, especially for calcium ions, which help to determine calcium in the presence of magnesium. It can be used experimentally for treating animals possessing cerium poisoning. It is useful in the separation of thorium from monazite. It also acts as a buffer and is used in protein purification.
Uses	A chelating agent useful for the determination of calcium in the presence of magnesium.
Definition	ChEBI: A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.
Biological Activity	Calcium chelator; protects against cell death caused by nitric oxide-induced calcium influx into nerve cells.
Safety Profile	Poison by intraperitoneal route. Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx. See also GLYCOL ETHERS.
Purification Methods	Dissolve EGTA in aqueous NaOH, precipitate it by adding aqueous HCl, wash it with water and dry at 100o in vacuo.[Beilstein 4 IV 217.]

Ethylenebis(oxyethylenenitrilo)tetraacetic acid Preparation Products And Raw materials

Raw materials

1,8-Diamino-3,6-dioxaoctane-->Chloroacetic acid

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