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| (R)-(+)-1,2-Dithiolane-3-pentanoic acid Basic information |
| (R)-(+)-1,2-Dithiolane-3-pentanoic acid Chemical Properties |
| Melting point | 48-52 °C(lit.) | | alpha | D23 +104° (c = 0.88 in benzene) | | Boiling point | 185-195 °C(Press: 0.5 Torr) | | density | 1.218±0.06 g/cm3(Predicted) | | refractive index | 114 ° (C=1, EtOH) | | Fp | >230 °F | | storage temp. | -20°C | | solubility | Acetonitrile (Slightly), Chloroform (Slightly), DMSO | | form | Solid | | pka | 5.4(at 25℃) | | color | Light Yellow to Yellow Low-Melting | | optical activity | [α]20/D +104°, c = 1 in chloroform | | Merck | 14,9326 | | CAS DataBase Reference | 1200-22-2(CAS DataBase Reference) |
| (R)-(+)-1,2-Dithiolane-3-pentanoic acid Usage And Synthesis |
| Chemical Properties | Yellow Crystalline Solid | | Uses | A fat-metabolism stimulator | | Uses | α-Lipoic acid has been used as a reference standard for the analysis of α-lipoic acid in human plasma by high performance liquid chromatography coupled to electron capture detector (HPLC-ECD), in various food matrices and dietary supplements by HPLC combined with coulometric electrode array detector (CEAD) as well as electrospray ionization mass spectrometer (ESI-MS). It may be used as a reference standard for the determination of α-lipoic acid in human urine by isocratic reversed-phase HPLC and in α-lipoic acid capsules by HPLC with chemiluminescence detection. | | General Description | α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms. | | Biochem/physiol Actions | (R)-(+)-α-Lipoic acid was shown to significantly increase pyruvate oxidation while abrogating fatty acid oxidation in rat hepatocytes. These effects make R-(+)-α-Lipoic acid a promising treatment option for the treatment of Type II diabetes. It is a biological antioxidant with prooxidant activities, its therapeutic potential is widely investigated, e.g. in the treatment for Alzheimer′s disease. |
| (R)-(+)-1,2-Dithiolane-3-pentanoic acid Preparation Products And Raw materials |
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