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| tert-Butyl bromoacetate Basic information |
| tert-Butyl bromoacetate Chemical Properties |
| Hazard Codes | Xi,F | | Risk Statements | 10-36/37/38 | | Safety Statements | 26-24/25-16 | | RIDADR | UN 1993 3/PG 3 | | WGK Germany | 3 | | F | 19 | | Hazard Note | Irritant/Flammable/Lachrymatory | | TSCA | T | | HazardClass | 3 | | PackingGroup | III | | HS Code | 29159080 |
| tert-Butyl bromoacetate Usage And Synthesis |
| Chemical Properties | clear colorless to yellow liquid | | Uses | tert-Butyl Bromoacetate is a halogenated t-butyl acetate commonly used as an alkylating agent. tert-Butyl Bromoacetate is used in the synthesis of collagenase inhibitors. | | Uses | tert-Butyl bromoacetate is used as an intermediate in the production of dyes, pharmaceuticals, agrochemicals and in organic compounds. It finds application as an alkylating agent. It plays an important role to prepare (2-oxo-4-vinyl-azetidin-1-yl)-acetic acid tert-butyl ester and in collagenase inhibitors synthesis. | | Application | tert-Butyl bromoacetate has been used in the synthesis of:nitrilotriacetic acid end-functionalized polystyrene by atom transfer radical polymerizationbuilding block for substituted t-butyl acetatesdihydropyranyl prelinker which is useful in polymer-assisted deprotection of oligosacchararidescollagenase inhibitor (S,S,R)-(-)-actinonin It is the starting reagent for the synthesis of N-Oxalylglycine derivatives. | | Preparation | Tert-butyl bromoacetate ester was synthesized using bromoacetic acid and isobutylene as raw materials,Amberlyst 15,a strong acidic cation exchange resin,as catalyst,and tert-butanol as modifier. | | General Description | tert-Butyl bromoacetate serves as building blocks during the synthesis of model N-substituted oligoglycines (peptoids) containing an N-linked lactoside side-chain. | | Flammability and Explosibility | Flammable | | Purification Methods | Dissolve the ester in Et2O, wash it well with ice cold 10% aqueous K2CO3, dry it over CaCl2, filter and evaporate the Et2O, then fractionate it through a Vigreux column (p 11) in a vacuum. LACHRYMATORY. [Abramovitch et al. J Am Chem Soc 64 2274 1942, Abramovitch & Hauser J Am Chem Soc 65 986 1943, Beilstein 2 III 482.] |
| tert-Butyl bromoacetate Preparation Products And Raw materials |
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