N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID

CAS No.：102507-13-1

Important Notice

This product is a chemical product/pharmaceutical intermediate. It is not a drug, an active pharmaceutical ingredient (API), or a pharmaceutical-grade material. It has not been granted a drug approval number or a Chemical Drug Substance Approval Notice, has not passed drug-related review and approval, and is not manufactured, tested, or released in accordance with pharmaceutical GMP.
This product is intended solely for non-clinical research, process development, quality studies, further chemical processing, or chemical synthesis. It must not be used in drug-product manufacturing, clinical trials, clinical diagnosis, or administration to humans or animals, or be sold, used as an input, submitted for regulatory filing, or released as an API or pharmaceutical material.
The purchaser must not use this product, or supply it to another party, for personal consumption, sports or fitness, weight loss, health supplements, food, or animal feed.

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N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Basic information

Product Name:	N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
Synonyms:	L-Threonine,N-[(1,1-diMethylethoxy)carbonyl]-3-Methyl-;EOS-60980;3-Hydroxy-L-valine, N-BOC protected;N-(tert-Butoxycarbonyl)-3-hydroxy-L-valine, (2S)-2-Amino-3-hydroxy-3-methylbutanoic acid, N-BOC protected;N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-L-threonine;(S)-N-ALPHA-T-BUTYLOXYCARBONYL-3,3-DIMETHYL-SERINE;(S)-2-BOC-AMINO-3-HYDROXY-3-METHYLBUTYRIC ACID;N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID
CAS:	102507-13-1
MF:	C10H19NO5
MW:	233.26
EINECS:
Product Categories:	unnatural amino acids;pharmacetical
Mol File:	102507-13-1.mol

N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Chemical Properties

Melting point	116-118℃
Boiling point	391.1±37.0 °C(Predicted)
density	1.175±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	3.62±0.10(Predicted)
color	White to Off-White

Safety Information

Risk Statements	36/37/38
Safety Statements	26-36/37/39
HazardClass	IRRITANT
HS Code	29225090

MSDS Information

N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Usage And Synthesis

Chemical Properties	White powder
Uses	N-Boc-3-hydroxy-L-valine is used as a reagent in the synthesis of metabolites of PPI-2458, which is a selective, irreversible inhibitor of methionine aminopeptidase-2 (MetAP2). N-Boc-3-hydroxy-L-valine is also used in the preparation of Boceprevir (B674500); an NS3 serine protease inhibitor of hepatitis C virus for the treatment of HCV infection.

N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Preparation Products And Raw materials

Raw materials

Carbamic acid, [2-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-, 1,1--->3-Oxazolidinecarboxylic acid, 4-(1-hydroxy-1-methylethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)--->BOC-D-SER-OME-->Carbamic acid, [(1R)-2-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-, 1,1--->(R)-2-Amino-3-hydroxy-3-methylbutanoic acid-->(S)-(+)-2-Amino-3-hydroxy-3-methylbutanoic acid-->Boc-L-serine methyl ester-->Di-tert-butyl dicarbonate-->Methylmagnesium Bromide-->Carbonic acid, bis(1,1-dimethylethyl) ester

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