Other grades of this product :
| N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Basic information |
| Product Name: | N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID | | Synonyms: | L-Threonine,N-[(1,1-diMethylethoxy)carbonyl]-3-Methyl-;EOS-60980;3-Hydroxy-L-valine, N-BOC protected;N-(tert-Butoxycarbonyl)-3-hydroxy-L-valine, (2S)-2-Amino-3-hydroxy-3-methylbutanoic acid, N-BOC protected;N-[(1,1-Dimethylethoxy)carbonyl]-3-methyl-L-threonine;(S)-N-ALPHA-T-BUTYLOXYCARBONYL-3,3-DIMETHYL-SERINE;(S)-2-BOC-AMINO-3-HYDROXY-3-METHYLBUTYRIC ACID;N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID | | CAS: | 102507-13-1 | | MF: | C10H19NO5 | | MW: | 233.26 | | EINECS: | | Product Categories: | unnatural amino acids;pharmacetical | | Mol File: | 102507-13-1.mol |
| N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Chemical Properties |
| Melting point | 116-118℃ | | Boiling point | 391.1±37.0 °C(Predicted) | | density | 1.175±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 3.62±0.10(Predicted) | | color | White to Off-White |
| N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Usage And Synthesis |
| Chemical Properties | White powder | | Uses | N-Boc-3-hydroxy-L-valine is used as a reagent in the synthesis of metabolites of PPI-2458, which is a selective, irreversible inhibitor of methionine aminopeptidase-2 (MetAP2). N-Boc-3-hydroxy-L-valine is also used in the preparation of Boceprevir (B674500); an NS3 serine protease inhibitor of hepatitis C virus for the treatment of HCV infection. |
| N-BOC-(S)-2-AMINO-3-HYDROXY-3-METHYLBUTANOIC ACID Preparation Products And Raw materials |
| Raw materials | Carbamic acid, [2-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-, 1,1--->3-Oxazolidinecarboxylic acid, 4-(1-hydroxy-1-methylethyl)-2,2-dimethyl-, 1,1-dimethylethyl ester, (4R)--->BOC-D-SER-OME-->Carbamic acid, [(1R)-2-hydroxy-1-(hydroxymethyl)-2-methylpropyl]-, 1,1--->(R)-2-Amino-3-hydroxy-3-methylbutanoic acid-->(S)-(+)-2-Amino-3-hydroxy-3-methylbutanoic acid-->Boc-L-serine methyl ester-->Di-tert-butyl dicarbonate-->Methylmagnesium Bromide-->Carbonic acid, bis(1,1-dimethylethyl) ester |
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